Selected Publications

DNA Repair & Nucleic Acid Enzymology Group

1. Wilson, S.H. and Kuff, E.L. A novel DNA polymerase activity found in association with intracisternal A-type particles. Proc. Natl. Acad. Sci. USA, 69:1531-153 6, 1972.  [Abstract] (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=4504367)
2. Matsukage, A., Bohn, E.W., and Wilson, S.H. Multiple forms of DNA polymerase in mouse myeloma. Proc. Natl. Acad. Sci. USA, 71:578-582, 1974.  [Abstract] (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=4521824)
3. Tanabe, K., Bohn, E.W., and Wilson, S.H. Steady-state kinetics of mouse DNA polymerase β. Biochemistry, 18:3401-3407, 1979.  [Abstract] (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=465481)
4. Zmudzka, B.Z., SenGupta, D., Matsukage, A., Cobianchi, F., Kumar, P., and Wilson, S.H. Structure of rat DNA polymerase β revealed by partial amino acid sequencing and cDNA cloning. Proc. Natl. Acad. Sci. USA, 83:5106-5110, 1986.  [Abstract] (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=2873575)
5. Widen, S., Kedar, P., and Wilson, S.H. Human β-polymerase gene: Structure of the 5' flanking region and active promoter. J. Biol. Chem., 263:16992-16998, 1988.  [Abstract] (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=3182828)
6. Beard, W.A. and Wilson, S.H. Kinetic analysis of template primer interactions with recombinant forms of HIV-1 reverse transcriptase. Biochemistry, 32:9745-9753, 1993.  [Abstract] (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=7690592)
7. Narayan, S., Widen, S.G., Beard, W.A., and Wilson, S.H. RNA polymerse II transcription: Rate of promoter clearance is enhanced by a purified activating transcription factor/cAMP response element-binding protein. J. Biol. Chem., 269, 12755-12763, 1994.  [Abstract] (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=8175688)
8. Sawaya, M.R., Pelletier, H., Kumar, A., Wilson, S.H., and Kraut, J. Crystal structure of rat DNA polymerase β: Evidence for a common polymerase mechanism. Science, 264:1930-1935, 1994.  [Abstract] (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=7516581)
9. Pelletier, H., Sawaya, M.R., Kumar, A., Wilson, S.H., and Kraut, J. Structures of ternary complexes of rat DNA polymerase β, a DNA template-primer, and ddCTP. Science, 264:1891-1903, 1994.  [Abstract] (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=7516580)
10. Singhal, R.K., Prasad, R., and Wilson, S.H. DNA polymerase β conducts the gap-filling step in uracil-initiated base excision repair in a bovine testis nuclear extract. J. Biol. Chem., 270:949-957, 1995.  [Abstract] (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=7822335)
11. Kunkel, T.A. and Wilson, S.H. DNA Repair. Push and pull of base flipping. Nature, 384:25-26, 1996.  [Abstract] (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=8900270)
12. Sobol, R.W., Horton, J.K., Kühn, R., Gu, H., Singhal, R.K., Prasad, R., Rajewsky, K., and Wilson, S.H. Requirement of mammalian DNA polymerase-β in base-excision repair. Nature, 379:183-186, 1996.  [Abstract] (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=8538772)
13. He, F., Narayan, S., and Wilson, S.H. Purification and characterization of a DNA polymerase β promoter initiator element-binding transcription factor from bovine testis. Biochemistry, 35:1775-1782, 1996.  [Abstract] (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=8639658)
14. Srivastava, D.K., Evans, R.K., Kumar, A., Beard, W.A., and Wilson, S.H. dNTP binding site in rat DNA polymerase β revealed by controlled proteolysis and azido photoprobe cross-linking. Biochemistry, 35:3728-3734, 1996.  [Abstract] (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=8619993)
15. Beard, W.A., Osheroff, W.P., Prasad, R., Jaju, M., Sawaya, M.R., Wood, T.G., Kraut, J., Kunkel, T.A., and Wilson, S.H. Enzyme-DNA interactions required for efficient nucleotide incorporation and discrimination in human DNA polymerase β. J. Biol. Chem., 271:12141-12144, 1996.  [Abstract] (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=8647805)
16. Beard, W.A., Minnick, D., Wade, C., Prasad, R., Won, R.L., Kumar, A., Kunkel, T.A., and Wilson, S.H. Role of the "Helix Clamp" in HIV-1 reverse transcriptase catalytic cycling as revealed by alanine-scanning mutagenesis. J. Biol. Chem., 271: 12213-12220, 1996.  [Abstract] (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=8647817)
17. Liu, D., Prasad, R., Wilson, S.H., DeRose, E.F., and Mullen, G.P. Three-dimensional solution structure of the N-terminal domain of DNA polymerase β and mapping of the ssDNA interaction interface. Biochemistry, 35:6188-6200, 1996.  [Abstract] (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=8639559)
18. Chyan, Y.-J., Strauss, P.R., Wood, T.G., and Wilson, S.H. Identification of novel mRNA isoforms for human DNA polymerase β. DNA and Cell Biology, 15:653-659, 1996.  [Abstract] (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=8769567)
19. Oda, N., Saxena, J.K., Jenkins, T.M., Prasad, R., Wilson, S.H., and Ackerman, E.J. DNA polymerases β and β are required for DNA repair in an efficient nuclear extract from Xenopus oocytes. J. Biol. Chem., 271:13816-13820, 1996.  [Abstract] (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=8662731)
20. Prasad, R., Singhal, R.K., Srivastava, D.K., Tomkinson, A.E., and Wilson, S.H. Specific interaction of DNA polymerase β and DNA ligase I in a multiprotein base excision repair complex from bovine testis. J. Biol. Chem., 271:16000-16007, 1996.  [Abstract] (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=8663274)
21. Piersen, C.E., Prasad, R., Wilson, S.H., and Lloyd, R.S. Evidence for an imino intermediate in the DNA polymerase β deoxyribose phosphate excision reaction. J. Biol. Chem., 271:17811-17815, 1996.  [Abstract] (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=8663612)
22. Narayan, S., He, F., and Wilson, S.H. Activation of the human DNA polymerase β promoter by a DNA-alkylating agent through induced phosphorylation of CREB-1. J. Biol. Chem., 271:18508-18513, 1996.  [Abstract] (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=8702497)
23. Lavrik, O.I., Prasad, R., Beard, W.A., Safronov, I.V., Dobrikov, M.I., Srivastava, D.K., Shishkin, G.V., Wood, T.G., and Wilson, S.H. dNTP binding to HIV-1 reverse transcriptase and mammalian DNA polymerase β as revealed by affinity labeling with a photoreactive dNTP analog. J. Biol. Chem., 271:21891-21897, 1996.  [Abstract] (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=8702991)
24. Pelletier, H., Sawaya, M.R., Wolfle, W., Wilson, S.H., and Kraut, J. Crystal structures of human DNA polymerase β complexed with DNA: Implications for catalytic mechanism, processivity, and fidelity. Biochemistry, 35:12742-12761, 1996.  [Abstract] (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=8841118)
25. Pelletier, H., Sawaya, M.R., Wolfle, W., Wilson, S.H., and Kraut, J. A structural basis for metal ion mutagenicity and nucleotide selectivity in human DNA polymerase β. Biochemistry, 35:12762-12777, 1996.  [Abstract] (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=8841119)
26. Reha-Krantz, L.J., Nonay, R.L., Day III, R.S., and Wilson, S.H. Replication of O6-Methylguanine-containing DNA by repair and replicative DNA polymerases. J. Biol. Chem., 271:20088-20095, 1996.  [Abstract] (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=8702729)
27. Mullen, G.P. and Wilson, S.H. Repair activity in DNA polymerases: a structurally conserved helix-hairpin-helix motif in base excision repair enzymes and in DNA polymerase β. IN: Hickson, I.D. (ed), Base Excision Repair of DNA Damage. Landes Bioscience, 1997, pp. 121-135.
28. Strauss, P.R., Beard, W.A., Patterson, T.A., and Wilson, S.H. Substrate binding by human apurinic/apyrimidinic endonuclease indicates a Briggs-Haldane Mechanism. J. Biol. Chem., 272:1302-1307, 1997.  [Abstract] (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=8995436)
29. Efrati, E., Tocco, G., Eritja, R., Wilson, S.H., and Goodman, M.F. Abasic translesion synthesis by DNA polymerase β violates the "A-Rule": Novel types of nucleotide incorporation by human DNA polymerase β at an abasic lesion in different sequence contexts. J. Biol. Chem., 272:2559-2569, 1997.  [Abstract] (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=8999973)
30. Forgacs, E., Latham, G., Beard, W.A., Prasad, R., Bebenek, K., Kunkel, T.A., Wilson, S.H., and Lloyd, R.S. Probing structure/function relationships of HIV-1 reverse transcriptase with styrene oxide N2-Guanine adducts. J. Biol. Chem., 272:8525-8530, 1997.  [Abstract] (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=9079681)
31. Kim, S., Merrill, B.M., Rajpurohit, R., Kumar, A., Stone, K.L., Papov, V.V., Schneidersm J.M., Szer, W., Wilson, S.H., Paik, W.K., and Williams, K.R. Identification of NG-Methylarginine residues in human heterogeneous RNP protein A1: Phe/Gly-Gly-Gly-Arg-Gly-Gly-Gly/Phe is a preferred recognition motif. Biochemistry, 36:5185-5192, 1997.  [Abstract] (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=9136880)
32. Mullen, G.P. and Wilson, S.H. DNA polymerase β in abasic site repair: a structurally conserved helix-hairpin-helix motif in lesion detection by base excision repair enzymes. Biochemistry, 36:4713-4717, 1997.  [Abstract] (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=9125491)
33. Bebenek, K., Beard, W.A., Darden, T.A., Li, L., Prasad, R., Luxon, B.A., Gorenstein, D.G., Wilson, S.H., and Kunkel, T.A. A minor groove binding track in reverse transcriptase. Nat. Struct. Biol., 4:194-197, 1997.  [Abstract] (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=9164459)
34. Butler, A.P., Johnson, D.G., Kumar, A.P., Narayan, S., Wilson, S.H., and MacLeod, M.C. Disruption of transcription in vitro and gene expression in vivo by DNA adducts derived from a benzo[a]pyrene diol epoxide located in heterologous sequences. Carcinogenesis, 18:239-244, 1997.  [Abstract] (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=9054613)
35. Mullen, G.P., Antuch, W., Maciejewski, M.W., Prasad, R., and Wilson, S.H. Insights into the mechanism of the β-elimination catalyzed by the N-terminal domain of DNA polymerase β. Tetrahedron, 53:12057-12066, 1997.
36. Sawaya, M.R., Prasad, R., Wilson, S.H., Kraut, J., and Pelletier, H. Crystal structures of human DNA polymerase β complexed with gapped and nicked DNA: evidence for an induced fit mechanism. Biochemistry, 36:11205-11215, 1997.  [Abstract] (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=9287163)
37. Yang, X-P., He, F., Rawson, T.Y., and Wilson, S.H. Human DNA polymerase β promoter: Phorbol ester activation is mediated through the cAMP response element and cAMP-response-element-binding protein. J. Biomed. Sci., 4:279-288, 1997.  [Abstract] (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=12386374)
38. Wilson, S.H., Sobol, R.W., Beard, W.A., Horton, J.K., Prasad, R., and Vande Berg, B.J. DNA polymerase-β and mammalian base excision repair. IN: Cold Spring Harbor Symposia on Quantitative Biology, Cold Spring Harbor Laboratory Press, 2000, Vol. 65, pp. 143-155.  [Abstract] (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=12760029)
39. Beard, W.A., Shock, D.D., Yang, X.-P., DeLauder, S.F., and Wilson, S.H. Loss of DNA polymerase β stacking interactions with templating purines, but not pyrimidines, alters catalytic efficiency and fidelity. J. Biol. Chem., 277:8235-8242, 2002.  [Abstract] (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=11756435)
40. Beard, W.A., Shock, D.D., Vande Berg, B.J., and Wilson, S.H. Efficiency of correct nucleotide insertion governs DNA polymerase fidelity. J. Biol. Chem., 277:47393-47398, 2002.  [Abstract] (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=12370169)
41. Beard, W.A., and Wilson, S.H. Structural insights into the origins of DNA polymerase fidelity. Structure (Camb.), 11:489-496, 2003.  [Abstract] (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=12737815)
42. Horton, J.K., Stefanick, D.F., Naron, J.M., Kedar, P.S., and Wilson, S.H. Poly(ADP-ribose) polymerase activity prevents signaling pathways for cell cycle arrest following DNA methylating agent exposure. J. Biol. Chem., 280:15773-15785, 2005.  [Abstract] (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15701627)
43. Batra, V.K., Beard, W.A., Shock, D.D., Pedersen, L.C., and Wilson, S.H. Nucleotide-induced DNA polymerase active site motions accommodating a mutagenic DNA intermediate. Structure (Camb.), 13:1225-1233, 2005.  [Abstract] (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=16084394)
44. Prasad, R., Batra, V.K., Yang, X.-P., Krahn, J.M., Pedersen, L.C., Beard, W.A., and Wilson, S.H. Structural insight into the DNA polymerase β deoxyribose phosphate lyase mechanism. DNA Repair (Amst.), 4:1347-1357, 2005.  [Abstract] (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=16172026)
45. Kirby, T.W., DeRose, E.F., Beard, W.A., Wilson, S.H., and London, R.E. A thymine isostere in the templating position disrupts assembly of the closed DNA polymerase β ternary complex. Biochemistry, 44:15230-15237, 2005.  [Abstract] (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=16285726)
46. Beard, W.A. and Wilson, S.H. Structure and mechanism of DNA polymerase β. Chemical Reviews, "DNA Damage and Repair," 106:361-382, 2006.  [Abstract] (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=16464010)
47. Batra, V.K., Beard, W.A., Shock, D.D., Krahn, J.M., Pedersen, L.C., and Wilson, S.H. Magnesium-induced assembly of a complete DNA polymerase catalytic complex. Structure (Camb.), 14:757-766, 2006.  [Abstract] (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=16615916)
48. Yoshimura, M., Kohzaki, M., Nakamura, J., Asagoshi, K., Sonoda, E., Hou, E., Prasad, R., Wilson, S.H., Tano, K., Yasui, A., Lan, L., Seki, M., Wood, R.D., Arakawa, H. Buerstedde, J.-M., Hochegger, H., Okada, T., Hiraoka, M., and Takeda, S. Vertebrate PolQ and Polβ cooperate in base excision repair of oxidative DNA damage. Mol. Cell, 24:115-125, 2006.  [Abstract] (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=17018297)
49. Lin, P., Pedersen, L.C., Batra, V.K., Beard, W.A., Wilson, S.H., and Pedersen, L.G. Energy analysis of chemistry for correct nucleotide insertion by DNA polymerase β. Proc. Natl. Acad. Sci. USA, 103:13294-13299, 2006.  [Abstract] (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=16938895)
50. Batra, V.K., Shock, D.D., Prasad, R., Beard, W.A., Hou, E.W., Pedersen, L.C., Sayer, J.M., Yagi, H., Kumar, S., Jerina, D.M., and Wilson, S.H. Structure of DNA polymerase β with a benzo[c]phenanthrene diol epoxide-adducted template exhibits mutagenic features. Proc. Natl. Acad. Sci. USA, 103:17231-17236, 2006.  [Abstract] (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=17079493)
51. Radhakrishnan, R., Arora, K., Wang, Y., Beard, W.A., Wilson, S.H., and Schlick, T. Regulation of DNA repair fidelity by molecular checkpoints: "Gates" in DNA polymerase β’s substrate selection. Biochemistry, 45:15142-15156, 2006.  [Abstract] (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=17176036)
52. Horton, J.K., Stefanick, D.F., Kedar, P.S., and Wilson, S.H. ATR signaling mediates an S-phase checkpoint after inhibition of poly(ADP-ribose) polymerase activity. DNA Repair (Amst.).  [Abstract] (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=17292679)
53. Wang Y, Reddy S, Beard WA, Wilson SH, Schlick T. Differing conformational pathways before and after chemistry for insertion of dATP vs. dCTP opposite 8-oxoG in DNA polymerase beta. Biophysical journal 9: 3063-3070, 2007. [Abstract] (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=17293403)
54. Das S, Chattopadhyay R, Bhakat KK, Boldogh I, Kohno K, Prasad R, Wilson SH, Hazra TK . Stimulation of NEIL2-mediated oxidized base excision repair via YB-1 interaction during oxidative stress. The Journal of biological chemistry 282(39):28474-28484, 2007. [Abstract] (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=17686777)
55. Moon AF, Garcia-Diaz M, Batra VK, Beard WA, Bebenek K, Kunkel TA, Wilson SH, Pedersen LC. The X family portrait: structural insights into biological functions of X family polymerases. DNA repair 6(12):1709-1725, 2007. [Abstract] (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=17631059)
56. Kovtun IV, Liu Y, Bjoras M, Klungland A, Wilson SH, McMurray CT. OGG1 initiates age-dependent CAG trinucleotide expansion in somatic cells. Nature 447(7143):447-452, 2007. [Abstract] (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=17450122)
57. Liu Y, Prasad R, Beard WA, Kedar PS, Hou EW, Shock DD, Wilson SH. Coordination of steps in single-nucleotide base excision repair mediated by apurinic/apyrimidinic endonuclease 1 and DNA polymerase β. The Journal of biological chemistry 282(18):13532-13541, 2007. [Abstract] (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=17355977)
58. Nakanishi S, Prasad R, Wilson SH, Smerdon M. Different structural states in oligonucleosomes are required for early versus late steps of base excision repair.. Nucleic Acids Research 35(13):4313-4321, 2007. [Abstract] (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=17576692)
59. Palma N, Cinelli S, Sapora O, Wilson SH, Dogliotti E. Ochratoxin A-induced mutagenesis in mammalian cells is consistent with production of oxidative stress.. Chemical research in toxicology 20(7):1031-1037 2007. [Abstract] (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=17576156)
60. Horton JK, Stefanick DF, Kedar PS, Wilson SH. ATR signaling mediates an S-phase checkpoint after inhibition of poly(ADP-ribose) polymerase activity. DNA repair 6(6):742-750, 2007. [Abstract] (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=17292679)
61. Tano K, Nakamura J, Asagoshi K, Arakawa H, Sonoda E, Braithwaite EK, Prasad R, Buerstedde J-M, Takeda S, Watanabe M, Wilson SH. Interplay between DNA polymerases beta and lambda in repair of oxidation DNA damage in chicken DT40 cells. DNA repair 6(6):869-875, 2007. [Abstract] (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=17363341)
62. Oelschlaeger P, Klahn M, Beard WA, Wilson SH, Warshel A. Magnesium-cationic dummy atom molecules enhance representation of DNA polymerase beta in molecular dynamics simulations: Improved accuracy in studies of structural features and mutational effects. Journal of molecular biology 366(2):687-701, 2007. [Abstract] (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=17174326)
63. Hou EW, Prasad R, Asagoshi K, Masaoka A, Wilson SH. Comparative assessment of plasmid and oligonucleotide DNA substrates in measurement of in vitro base excision repair activity. Nucleic acids research 35(17):e112, 2007. [Abstract] (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=17720705)
64. McKenna CE, Kashemirov BA, Upton TG, Batra VK, Goodman MF, Pedersen LC, Beard WA, Wilson SH . (R)-beta,gamma-fluoromethylene-dGTP-DNA ternary complex with DNA polymerase beta. Journal of the American Chemical Society 129(50):15412-15413, 2007. [Abstract] (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=18031037)
65. Prasad R, Liu Y, Deterding LJ, Poltoratsky VP, Kedar PS, Horton JK, Kanno SI, Asagoshi K, Hou EW, Khodyreva SN, Lavrik OI, Tomer KB, Yasui A, Wilson SH. HMGB1 is a co-factor in mammalian base excision repair. Molecular cell 27(5):829-841, 2007. [Abstract] (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=17803946)
66. Horton JK, Watson M, Stefanick DF, Shaughnessy DT, Taylor JA, Wilson SH. XRCC1 and DNA polymerase beta in cellular protection against cytotoxic DNA single-strand breaks. Cell research 18(1):48-63, 2008. [Abstract] (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=18166976)
67. Xiang Y, Goodman MF, Beard WA, Wilson SH, Warshel A. Exploring the role of large conformational changes in the fidelity of DNA Polymerase beta. Proteins 70(1):231-247, 2008. [Abstract] (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=17671961)
68. Batra VK, Beard WA, Shock DD, Pedersen LC, Wilson SH. Structures of DNA polymerase beta with active site mismatches suggest a transient abasic site intermediate during misincorporation. Molecular cell 30(3):315-324, 2008. [Abstract] (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=18471977)
69. Kronenberg G, Harms C, Sobol RW, Cardozo-Pelaez F, Linhart H, Winter B, Balkaya M, Gertz K, Gay SB, Cox D, Eckart S, Ahmadi M, Juckel G, Kempermann G, Hellweg R, Sorh R, Hortnagl H, Wilson SH, Jaenisch R, Endres M. Folate deficiency induces neurodegeneration and brain dysfunction in mice lacking uracil DNA glycosylase.. The Journal of neuroscience : the official journal of the Society for Neuroscience 28(28):7219-7230, 2008. [Abstract] (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=18614692)
70. Kedar PS, Stefanick DF, Horton JK, Wilson SH. Interaction between PARP-1 and ATR in mouse fibroblasts is blocked by PARP inhibition. DNA repair 7(11):1787-1798, 2008. [Abstract] (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=18691676)
71. Allen D, Herbert DC, McMahan CA, Rotrekl V, Sobol RW, Wilson SH, Walter CA. Mutagenesis is elevated in male germs cells obtained from DNA polymerase-beta heterozygous mice. Biology of reproduction 79(5):824-831, 2008. [Abstract] (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=18650495)
72. Poltoratsky VP, Horton, JK, Prasad, R, Beard, WA, Woodgate, R, Wilson, SH. Negligible impact of pol iota expression on the alkylation sensitivity of pol beta-deficient mouse fibroblast cells. DNA repair 7(6):830-833, 2008. [Abstract] (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=18434259)

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