MENTORED PATIENT-ORIENTED RESEARCH CAREER DEVELOPMENT AWARD (K23)

Release Date:  October 8, 1999 (This PA has been reissued, see PA-05-0143)
                               (See update, NOT-MH-05-008)
                               (See update, NOT-DA-05-005)
                               (Expiration date extended, see NOT-OD-05-011) 
                               (see NOT-DA-05-001, NOT-EB-03-005 and NOT-NS-03-001)

PA NUMBER:  PA-00-004

EXPIRATION DATE:  October 08, 2005, unless reissued

National Institute on Aging
National Institute on Alcohol Abuse and Alcoholism
National Institute of Allergy and Infectious Diseases
National Institute of Arthritis and Musculoskeletal and Skin Diseases
National Cancer Institute
National Institute of Child Health and Human Development
National Institute on Deafness and Other Communication Disorders
National Institute of Dental and Craniofacial Research
National Institute of Diabetes and Digestive and Kidney Diseases
National Institute on Drug Abuse
National Institute of Environmental Health Sciences
National Eye Institute
National Institute of General Medical Sciences
National Heart, Lung, and Blood Institute
National Institute of Mental Health
National Institute of Neurological Disorders and Stroke
National Institute of Nursing Research
National Center for Complementary and Alternative Medicine
National Center for Research Resources

Special Note:  In the early stages of application preparation, all candidates
should contact the prospective NIH awarding component listed at the end of
this program announcement to discuss issues of eligibility and the specific
provisions of this award.

PURPOSE

The purpose of the Mentored Patient-oriented Research Career Development Award
(K23) is to support the career development of investigators who have made a
commitment to focus their research endeavors on patient-oriented research.
This mechanism provides support for three to five years of supervised study
and research for clinically trained professionals who have the potential to
develop into productive, clinical investigators focussing on patient-oriented
research.  Clinically trained professionals or individuals with a clinical
degree who are interested in further career development in biomedical research
that is not patient-oriented, should refer to the Mentored Clinical Scientist
Career Development (K08) Award (see
http://grants.nih.gov/training/careerdevelopmentawards.htm on the NIH website
for details).

For the purposes of this award, patient-oriented research is defined as
research conducted with human subjects (or on material of human origin such as
tissues, specimens, and cognitive phenomena) for which an investigator
directly interacts with human subjects.  This area of research includes: 1)
mechanisms of human disease; 2) therapeutic interventions; 3) clinical trials,
and; 4) the development of new technologies.

The National Institutes of Health (NIH) is especially interested in increasing
the number of clinicians trained to conduct high-quality, patient-oriented
clinical research.  Accordingly, this award forms an important part of the NIH
initiative to attract talented individuals to the challenges of clinical
research.  NIH intends to target a significant increase in funds for these
entry-level career development awards through 2003.  The K23 provides the
awardee, through multidisciplinary didactic training, the opportunity to
obtain both the knowledge and the research skills necessary to compete for
independent support in patient-oriented research.  This initiative is
consistent with the recommendations of the NIH Director's Panel on Clinical
Research and the recommendations from the Institute of Medicine Committee on
Addressing Career Paths for Clinical Research.

The objectives of the Mentored Patient-Oriented Research Career Development
Award (K23) are to:

o encourage research-oriented clinicians to develop independent research
skills and gain experience in advanced methods and experimental approaches
needed to conduct patient-oriented research

o increase the pool of clinical researchers who can conduct patient-oriented
studies, capitalizing on the discoveries of biomedical research and
translating them to clinical settings

In the early stages of application preparation, all candidates should contact
the prospective NIH awarding component listed at the end of this announcement
to discuss issues of eligibility and the specific provisions of this award.
      
HEALTHY PEOPLE 2000

The Public Health Service (PHS) is committed to achieving the health promotion
and disease prevention objectives of "Healthy People 2000," a PHS led national
activity for setting priority areas. This Program Announcement (PA), the
Mentored Patient-Oriented Research Career Development Award (K23), is related
to one or more of the priority areas.  Potential applicants may obtain a copy
of "Healthy People 2000" at http://odphp.osophs.dhhs.gov/pubs/hp2000.

ELIGIBILITY REQUIREMENTS

The candidate must have a clinical doctoral degree or its equivalent. 
Illustrative examples include, but are not limited to: M.D., D.D.S., D.M.D.,
D.O., D.C., O.D., N.D. (Doctor of Naturopathy), D.V.M., Pharm.D., or the Ph.D.
or other doctoral degree in disciplines such as clinical psychology, nursing,
clinical genetics, speech-language pathology, audiology and rehabilitation. 
Individuals holding the Ph.D. in a non-clinical discipline but are certified
to perform clinical duties should contact the appropriate Institute concerning
their eligibility for a K23 award.

Candidates also must have completed their clinical training, including
specialty and, if applicable, subspecialty training prior to receiving an
award.  However, candidates may submit an application prior to the completion
of clinical training.  Candidates must identify a mentor with extensive
research experience, and must be willing to spend a minimum of 75 percent of
full-time professional effort conducting research career development and
clinical research.

Applications may be submitted, on behalf of candidates, by domestic, non-
Federal organizations, public or private, such as medical, dental, or nursing
schools or other institutions of higher education.  Minorities, women and
individuals with disabilities are encouraged to apply.  At time of award,
candidates must be citizens or noncitizen nationals of the United States, or
have been lawfully admitted to the United States for permanent residence
(i.e., in possession of a currently valid Alien Registration Receipt Card I-
551, or other legal verification of such status).  Noncitizen nationals are
generally persons born in outlying possessions of the United States (i.e.,
American Samoa and Swains Island).  Individuals on temporary or student visas
are not eligible.

Ineligible individuals include current and former principal investigators on
NIH research project (R01), FIRST Awards (R29), comparable career development
awards (K01, K07, or K08), sub-projects of program project (P01) or center
grants (P50), and the equivalent.  Former principal investigators of NIH Small
Grants (R03) or Exploratory/Developmental Grants (R21) remain eligible. 
Current and former recipients of Clinical Associate Physicians Award (CAP)
support may apply for the K23 provided they've had no more than 3 years of CAP
support by the time of the K23 award.  The combined total of CAP plus K23
support must not exceed 6 years.  A candidate for the K23 award may not have
pending nor concurrently apply for a CAP award or any other career development
award.  K23 recipients are encouraged to apply for independent research grant
support during the period of this award.

MECHANISM OF SUPPORT

Awards in response to this program announcement will use the K23 mechanism.
Planning, direction, and, execution of the program will be the responsibility
of the candidate and her/his mentor on behalf of the applicant institution.
The project period may be for up to five years with a minimum of three years.
Awards are not renewable.

AWARDS AVAILABLE

The overall goal of the NIH is to support approximately 80 competing awards in
Fiscal Year 1999 and in each succeeding year through Fiscal Year 2003. The
actual number of awards to be made by each Institute or Center will vary
yearly and will be dependent upon the number and quality of applications
submitted and funds available.

RESEARCH OBJECTIVES

A. Environment:  The institution must have a well-established research and
clinical career development program. It must also have faculty qualified in
clinical research with an emphasis on patient-oriented research to serve as
mentors.  The institution must be able to demonstrate a commitment to the
development of the candidate as a productive, independent investigator.  The
candidate, mentor, and institution must be able to describe an in-depth, multi
disciplinary career development program that will utilize the relevant
research and educational resources.

B. Program:  The award provides up to five consecutive 12-month awards. At
least 75 percent of the recipient's full-time professional effort must be
devoted to the goals of this award.  The remainder may be devoted to clinical,
teaching, or other research pursuits consistent with the objectives of the
award. Both the didactic and the research phases of an award period must be
designed to develop the necessary knowledge and research skills in scientific
areas relevant to the career goals of the candidate.  Candidates must
demonstrate they have received or will participate in courses such as: data
management, epidemiology, study design, hypothesis development, drug
development, etc., as well as the legal and ethical issues associated with
research on human subjects.

Because of the focus on progression to independence as a researcher,
candidates for the K23 should propose a period of study and career development
consistent with her or his previous research and clinical experience. For
example, a candidate with limited experience in a given field of research may
find a phased developmental program lasting five years that includes a
designated period of didactic training followed by a period of closely
supervised research experience the most efficient means of attaining
independence. A candidate with previous research experience and training may
not require extensive additional didactic preparation and a program that
focuses on an intensive, supervised patient-oriented research experience may
be appropriate. All programs must be tailored to meet the individual needs of
the candidate ensuring that he/she will gain the skills and knowledge
necessary to carry out high quality patient-oriented research.  The candidate
and the mentor are jointly responsible for the preparation of the plan for
this program. The sponsor may form an advisory committee to assist with the
development of a program of study or to monitor the candidate's progress
through the career development program.  The didactic and research components
of both phases must develop new knowledge and research skills in scientific
areas relevant to the career goals of the candidate.  While the focus of the
career development program is on the conduct of patient-oriented research,
there can be complementary laboratory research directly related to the
patient-oriented research proposed in the application.

C. Mentor(s): Candidates must name a primary sponsor (or mentor), who together
with the applicant is responsible for the planning, direction, and execution
of the program. The mentor should be recognized as an accomplished
investigator in the proposed research area and have a track record of success
in training independent investigators. The mentor should have sufficient
independent research support to cover the costs of the proposed research
project in excess of the allowable costs of this award. Candidates may also
nominate co-mentors as appropriate to the goals of the program.  Where
feasible, women, minority individuals and individuals with disabilities should
be involved as mentors to serve as role models.

D. Allowable Costs:

1. Salary:  The NIH will provide salary and fringe benefits for the career
award recipient. The total salary requested must be based on a full-time, 12-
month staff appointment.  It must be consistent both with the established
salary structure at the institution and with salaries actually provided by the
institution from its own funds to other staff members of equivalent
qualifications, rank, and responsibilities in the department concerned.  If
full-time, 12-month salaries are not currently paid to comparable staff
members, the salary proposed must be appropriately related to the existing
salary structure.

Most NIH awarding components will provide up to $75,000 to offset the full-
time salary requirements of the candidate.  But, salary limits on career
awards are not uniform throughout the NIH and in some cases may vary.  And, in
exceptional circumstances, individual NIH awarding components may be able to
make exceptions to their stated maximum levels provided the total salary does
not exceed the current legislated maximum ($125,900 in Fiscal 1999).
Therefore, prospective candidates should contact the NIH component to which
the application is targeted to ascertain the maximum contribution to the
candidate's salary.

The institution may supplement the NIH salary contribution up to a level that
is consistent with the institution's salary scale; however, supplementation
may not be from Federal funds unless specifically authorized by the Federal
program from which such funds are derived.  Because the salary amount provided
by this award is based on the full-time institutional salary, no other PHS
funds may be used for salary supplementation.  Institutional supplementation
of salary must not require extra duties or responsibilities that would
interfere with the purpose of the K23.  Under expanded authorities, however,
institutions may rebudget funds within the total costs awarded to cover
salaries consistent with the institution's salary scale.

2. Research Development Support: The NIH will provide generally up to $25,000
per year for the following expenses: (a) tuition, fees, and books related to
career development; (b) research expenses, such as supplies, equipment and
technical personnel; c) travel to research meetings or training; (d)
statistical services including personnel and computer time.  In exceptional
cases, the Research Development Support costs may be as high as $50,000, but
such costs will only be awarded in those cases where the need for such higher
costs is well documented and adequately justified.  Prospective candidates
should contact the NIH component to which the application is targeted to
ascertain the maximum contribution for research and development support.

3. Ancillary Personnel Support: Salary for mentors, secretaries and
administrative assistants is not allowed.

4. Facilities and Administrative Costs: These costs, which were formerly
called indirect costs, will be reimbursed at 8 percent of modified total
direct costs.

E. Evaluation:  In carrying out its stewardship of human resource related
programs, the NIH may begin requesting information essential to an assessment
of the effectiveness of this program.  Accordingly, recipients are hereby
notified that they may be contacted after the completion of this award for
periodic updates on various aspects of their employment history, publications,
support from research grants or contracts, honors and awards, professional
activities, and other information helpful in evaluating the impact of the
program.

F. Other Income: Fees resulting from clinical practice, professional
consultation, or other comparable activities required by the research and
research-related activities of this award may not be retained by the career
award recipient.  Such fees must be assigned to the grantee institution for
disposition by any of the following methods:

o The funds may be expended by the grantee institution in accordance with the
NIH policy on supplementation of career award salaries and to provide fringe
benefits in proportion to such supplementation. Such salary supplementation
and fringe benefit payments must be within the established policies of the
grantee institution.

o The funds may be used for health-related research purposes.

o The funds may be paid to miscellaneous receipts of the U.S. Treasury. Checks
should be made payable to the Department of Health and Human Services, NIH and
forwarded to the Director, Office of Financial Management, NIH, Bethesda,
Maryland  20892.  Checks must identify the relevant award account and reason
for the payment.

o Awardees may retain royalties and fees for activities such as scholarly
writing, service on advisory groups, or honoraria from other institutions for
lectures or seminars, provided these activities remain incidental and provided
that the retention of such pay is consistent with the policies and practices
of the grantee institution.

Usually, funds budgeted in an NIH supported research or research training
grant for the salaries or fringe benefits of individuals, but freed as a
result of a career award, may not be rebudgeted.  The awarding component will
give consideration to approval for the use of released funds only under
unusual circumstances.  Any proposed retention of funds released as a result
of a career award must receive prior written approval of the NIH awarding
component.

G. Special Leave: Leave to another institution, including a foreign laboratory
may be permitted if the proposed experience is directly related to the purpose
of the award.  Only local, institutional approval is required if such leave
does not exceed 3 months.  For longer periods, prior written approval of the
NIH funding component is required.  To obtain prior approval, the award
recipient must submit a letter to the NIH funding component describing the
plan, countersigned by his or her department head and the appropriate
institutional official.  A copy of a letter or other evidence from the
institution where the leave is to be taken must be submitted to assure that
satisfactory arrangements have been made.  Support from the career award will
continue during such leave.

Leave without award support may not exceed 12 months.  Such leave requires the
prior written approval of the NIH funding component and will be granted only
in unusual situations.  Support from other sources is permissible during the
period of leave.  Such leave does not reduce the total number of months of
program support for which an individual is eligible.

Under unusual and pressing circumstances, an awardee may submit a written
request to the awarding component, requesting a reduction in professional
effort below 75 percent.  Such requests will be considered on a case-by-case
basis during the award period.  In no case, will it be permissible to work at
a rate of less than 50 percent effort.  The nature of the circumstances
requiring reduced effort might include medical conditions, disability, or
pressing personal or family situations such as child or elder care. 
Permission to reduce the level of effort will not be approved to accommodate
other sources of funding, job opportunities, clinical practice, or clinical
training.  In each situation, the grantee institution must submit
documentation supporting the need for reduced effort along with assurance of a
continuing commitment to the scientific development of the awardee.  Further,
the awardee must submit assurance of his or her intention to return to full-
time professional effort (at least 75 percent) as soon as possible.  During
the period of reduced effort, the salary and other costs supported by the
award will be reduced accordingly.

H. Termination or Change of Institution: When a grantee institution plans to
terminate an award, the NIH funding component must be notified in writing at
the earliest possible time so that appropriate instructions can be given for
termination. The Director of the NIH may discontinue an award upon
determination that the purpose or terms of the award are not being fulfilled. 
In the event an award is terminated, the Director of the NIH shall notify the
grantee institution and career award recipient in writing of this
determination, the reasons therefor, the effective date, and the right to
appeal the decision.

Awardees planning a change of institution, must submit to the funding NIH
component in advance of the change a written request for transfer,
countersigned by the appropriate institutional business official, describing
the reasons for the change and including the new sponsor's name and biosketch. 
The awardee must establish in this request that the specific aims of the
research program to be conducted at the new institution are within the scope
of the original peer reviewed research program.  Additionally, the new sponsor
must have the appropriate research expertise to supervise the program and
sufficient research support to ensure continuation of the research program to
the end of the award (initial award).  Staff within the NIH funding component
will review this request and may require a review by an initial review group
and/or the appropriate national advisory council or board. Upon approval of
this request, a new career award application must be submitted by the new
institution far enough in advance of the requested effective date to permit
review.  The period of support requested in the new application must be no
more than the time remaining within the existing award period.

When a mentor at the grantee institution is to be replaced, the institution
must submit a letter from the proposed mentor documenting the need for
substitution, the new mentor's qualifications for supervising the program, and
the level of support for the candidate's career development.  The letter must
also document that the specific aims of the research program will remain
within the scope of the original peer reviewed research program.  Staff within
the NIH funding component will review the request, and will notify the grantee
institution of the results of the evaluation.

A final progress report, invention statement, and Financial Status Report are
required upon either termination of an award or relinquishment of an award in
a change of institution situation.

INCLUSION OF WOMEN AND MINORITIES IN RESEARCH INVOLVING HUMAN SUBJECTS

It is the policy of the NIH that women and members of minority groups and
their subpopulations must be included in all NIH supported biomedical and
behavioral research projects involving human subjects, unless a clear and
compelling rationale and justification is provided that inclusion is
inappropriate with respect to the health of the subjects or the purpose of the
research. This policy results from the NIH Revitalization Act of 1993 (Section
492B of Public Law 103-43).

All investigators proposing research involving human subjects should read the
"NIH Guidelines For Inclusion of Women and Minorities as Subjects in Clinical
Research," which have been published in the Federal Register of March 28, 1994
(FR 59 14508-14513) and in the NIH Guide for Grants and Contracts, Vol. 23,
No. 11, March 18, 1994 available on the web at the following URL address:
http://grants.nih.gov/grants/guide/notice-files/not94-100.html

INCLUSION OF CHILDREN AS PARTICIPANTS IN RESEARCH INVOLVING HUMAN SUBJECTS

It is the policy of NIH that children (i.e., individuals under the age of 21)
must be included in all human subjects research, conducted or supported by the
NIH, unless there are scientific and ethical reasons not to include them. This
policy applies to all initial (Type 1) applications submitted for receipt
dates after October 1, 1998.

All investigators proposing research involving human subjects should read the
"NIH Policy and Guidelines on the Inclusion of Children as Participants in
Research Involving Human Subjects" that was published in the NIH Guide for
Grants and Contracts, March 6, 1998, and is available at the following URL
address: http://grants.nih.gov/grants/guide/notice-files/not98-024.html

Investigators also may obtain copies of these policies from the program staff
listed under INQUIRIES. Program staff may also provide additional relevant
information concerning the policy.

APPLICATION PROCEDURES

Potential candidates are strongly encouraged to contact the staff person in
the relevant institute or center listed under INQUIRIES.  Such contact should
occur early in the planning phase of application preparation.  Such contact
will help ensure that applications are responsive to the goals and policies of
the individual institute or center.

Applicants who will be using the resources within a General Clinical Research
Center (GCRC) during the course of the award are requested to include a letter
of agreement from either the GCRC program director or the principal
investigator with the application.

Applications are to be prepared using Section IV of the grant application form
PHS 398 (rev. 4/98).  Applications will be accepted on or before the receipt
dates indicated in the application kit.  Forms are available at most
institutional offices of sponsored research and from the Division of
Extramural Outreach and Information Resources, National Institutes of Health,
6701 Rockledge Drive, MSC 7910, Bethesda, MD 20892-7910, Phone (301) 435-0714,
FAX: (301) 480-0525, Email: GrantsInfo@nih.gov.

Forms are also available on the NIH Website at
http://grants.nih.gov/grants/funding/phs398/phs398.html

To identify the application as a response to this program announcement, check
"YES" on item 2 of page 1 of the application and enter "PA-00-004 MENTORED
PATIENT-ORIENTED RESEARCH CAREER DEVELOPMENT AWARD."

Submit a signed, typewritten original of the application with Checklist, and
five signed photocopies, in one package to:

CENTER FOR SCIENTIFIC REVIEW
NATIONAL INSTITUTES OF HEALTH
6701 ROCKLEDGE DRIVE, ROOM 1040 - MSC 7710
BETHESDA, MD  20892-7710
BETHESDA, MD  20817-7710 (for express/courier service)

The application must contain the following:

Candidate

o A description of the candidate's commitment to a career in patient-oriented
research.

o Evidence of the candidate's potential to develop into an independent
investigator.

o A description of immediate and long-term career objectives, explaining how
the award will contribute to their attainment.

o A commitment of at least 75 percent effort to the clinical research program.

o Three sealed letters of recommendation addressing the candidate's potential
for a research career. The mentor's statement (see below) must not be included
as one of the letters of recommendation.

Career Development Plan

o A description of the career development plan, incorporating consideration of
the candidate's goals and prior experience.  It must describe a systematic
plan to obtain the necessary theoretical and conceptual background, in
addition to the research experience and skills, necessary to launch an
independent career in clinical research.  Candidates must describe the
availability of courses such as research design, biostatistics, epidemiology,
and ethical and regulatory issues at their institution and the integration of
these studies into their career development plan.  Less experienced candidates
may require a phased developmental period in which the first one to two
year(s) of the award are largely of a didactic nature followed by a period of
intense, supervised research experience. Candidates with more experience at
the time of application may need a shorter didactic period and may already
have an adequate theoretical background. In any case, the career development
plan must be specifically tailored to the needs of the individual candidate
and the ultimate goal of achieving independence as a clinical researcher.

Training in the Responsible Conduct of Research

o Candidates must describe plans to receive instruction in the responsible
conduct of research. These plans must detail the proposed subject matter,
format, frequency, and duration of instruction.  No award will be made if an
application lacks this component.

Research Plan

o A description of the clinical research plan. The research plan must be
described as outlined in form PHS 398 including sections on the Specific Aims,
Background and Significance, Progress Report/Preliminary Studies, Research
Design and Methods.  The candidate should consult with the mentor regarding
the development of this section.

Mentor's Statement

o The application must include a statement from the mentor including
information on his or her qualifications in the research area proposed by the
candidate and previous experience as a research supervisor.  The application
must also include information to describe the nature and extent of supervision
that will occur during the proposed award period.

o Similar information must be provided by any co-mentor.  If more than one
mentor is proposed, the respective areas of expertise and responsibility
should be described.

Environment and Institutional Commitment

o The sponsoring institution must document a strong, well-established research
and training program related to the candidate's area of interest including a
high-quality research environment with staff capable of productive
collaboration with the candidate. The sponsoring institution must provide a
statement of commitment to the candidate's development into a productive,
independent investigator.  The institutional statement also must commit to
provision of release time from normal clinical, teaching or administrative
duties necessary to meet the 75% effort requirement of this award.

Budget

o The total direct costs requested must be consistent with this K23 program
announcement and the award limits of the NIH funding component.  Applicants
seeking information on award limits should contact the likely funding
component listed in the INQUIRIES section of this program announcement.

REVIEW CONSIDERATIONS

Applications will be reviewed for completeness by the Center for Scientific. 
Incomplete applications will be returned to the applicant without further
consideration.  Applications that are complete will be evaluated for
scientific and technical merit by a peer review group convened by the
sponsoring NIH Institute/Center or by the NIH Center for Scientific Review in
accordance with the standard NIH peer review procedures.  As part of the
initial merit review, all applications will receive a written critique. 
Applications may undergo a streamlined review process.  In this process, only
those applications deemed to have the highest scientific merit, generally the
top half of applications under review, will be discussed, assigned a priority
score, and receive a second level review by the appropriate national advisory
council or board.

The following review criteria will be applied:

Candidate

o Quality of the candidate's academic and clinical record,

o Potential to develop as an independent clinical researcher focusing on
patient-oriented research;

o Commitment to a career in patient-oriented research.

Career Development Plan

o Likelihood that the career development plan will contribute substantially to
the scientific development of the candidate;

o Appropriateness of the content and duration of the proposed didactic and
research phases of the award; and

o Consistency of the career development plan with the candidate's career goals
and prior research experience.

Training in the Responsible Conduct of Research

o Quality of the proposed training in responsible conduct of research.

Research Plan

Reviewers recognize that an individual with limited research experience is
less likely to be able to prepare a research plan with the breadth and depth
of that submitted by a more experienced investigator.  Nevertheless, a
fundamentally sound research plan must be provided.  For candidates who
require substantial didactic training as part of their program, the research
plan may cover less than the full period of  the award.

o Scientific and technical merit of the research question, design and
methodology;

o Relevance of the proposed research to the candidate's career objectives; and

o Appropriateness of the research plan to the stage of research development
and as a vehicle for developing the research skills as described in the career
development plan;

o Adequacy of the plan's attention to gender and minority issues associated
with projects involving human subjects.

o Adequacy of plans for including children, as appropriate, for the scientific
goals of the research, or justification for exclusion.

Mentor/Co-Mentor

o Appropriateness of mentor(s) research qualifications in the area of this
application;

o Quality and extent of mentor's proposed role in providing guidance and
advice to the candidate;

o Previous experience in fostering the development of more junior researchers;

o History of research productivity and support; and

o Adequacy of support for the proposed research project.

Environment and Institutional Commitment

o Adequacy of research facilities and the availability of appropriate
educational opportunities;

o Quality and relevance of the environment for scientific and professional
development of the candidate;

o Applicant institution's commitment to the scientific development of the
candidate and assurances that the institution intends the candidate to be an
integral part of its research program; and

o Applicant institution's commitment to an appropriate balance of research and
clinical responsibilities including the commitment of 75 percent of the
candidate's effort to research and research related activities.

Budget

o Justification of the requested budget in relation to career development
goals and research aims.

AWARD CRITERIA

Funding decisions will be made based on the recommendations of the initial
review group and Advisory Council/Board, the need for research personnel in
specific program areas, and the availability of funds.

INQUIRIES

Written and telephone inquiries concerning this program announcement are
strongly encouraged especially during the planning phase of the application.
Below is a listing of each institute's or center's program contact.

Direct inquiries regarding programmatic issues to:

National Institute on Aging
Additional information about the career awards program at NIA is available
from: http://www.nih.gov/nia/

Dr. Robin A. Barr
Office of Extramural Affairs
7201 Wisconsin Avenue, Room 2C218, MSC 9205
Bethesda, MD  20892-9205
Telephone:  (301) 496-9322
FAX:  (301) 402-2945
Email:  rb42h@nih.gov

National Institute on Alcohol Abuse and Alcoholism 
Ernestine Vanderveen, Ph.D. 
Division of Basic Research, NIAAA
6000 Executive Boulevard, Suite 402, MSC 7003 
Bethesda, MD 20892-7003 
Telephone: 301-443-2531 
Fax: 301-594-0673 
E-mail: tvanderv@willco.niaaa.nih.gov

Harold I. Perl, Ph.D.
Division of Clinical and Prevention Research, NIAAA 
6000 Executive Boulevard, Suite 505, MSC 7003 
Bethesda, MD 20892-7003 
Telephone: 301-443-0788 
Fax: 301-443-8774 
E-mail: hperl@willco.niaaa.nih.gov 

Vivian B. Faden, Ph.D.
Division of Biometry and Epidemiology, NIAAA
6000 Executive Boulevard, Suite 514, MSC 7003 
Bethesda, MD 20892-7003 
Telephone: 301-594-6232 
Fax: 301-443-8614 
E-mail: vfaden@willco.niaaa.nih.gov

National Institute of Allergy and Infectious Diseases
Dr. Milton Hernandez
Office of Scientific Training and Manpower Development
Solar Building, Room 3C21
Bethesda, MD  20892
Telephone:  (301) 496-7291
FAX:  (301) 402-0369
Email:  mh35c@nih.gov

National Institute on Arthritis and Musculoskeletal and Skin Diseases
Richard W. Lymn, Ph.D.
Research Training Officer
National Institute of Arthritis and Musculoskeletal and Skin Diseases
Building 45, Room 5AS-49E
Bethesda, MD  20892-6500
Telephone:  (301) 594-5128
FAX:  (301) 480-4543
Email:  richard_w_lymn@nih.gov

National Cancer Institute
Dr. Lester S. Gorelic or Dr. Andrew Vargosko
National Cancer Institute
Office of the Deputy Director for Extramural Sciences
Office of Centers, Training and Resources
Executive Plaza North, Room 520, MSC 7390
Bethesda, MD  20892-7390
Telephone:  (301) 496-8580
FAX:  (301) 402-4472
Email: lg2h@nih.gov or av8b@nih.gov

The following paragraph added 10-05-01.

Individuals conducting mentored, patient-oriented research in the cancer 
prevention, control, behavioral or the population sciences should refer to the 
NCI's specialized use of the K07, the "Prevention, Control, Behavioral and 
Population Sciences Career Development Award."  For information on this award 
please contact Dr. Maria Agelli, ma215e@nih.gov.

National Institute of Child Health and Human Development
Steven L. Klein, Ph.D.
Developmental Biology, Genetics & Teratology Branch
Building 6100, Room 4B01 MSC 7510
Bethesda, MD 20892-7510
Telephone: 301-496-5541
FAX: 301-480-0303
Email: KleinS@Exchange.nih.gov

National Institute on Deafness and Other Communication Disorders
Daniel A. Sklare, Ph.D.
Division of Human Communication
Executive Plaza South, Room 400C-13
6120 Executive Blvd., MSC 7180
Bethesda, MD  20892-7180
Telephone:  (301) 496-1804
FAX:  (301) 402-6251
Email:  Daniel_Sklare@nih.gov

National Institute of Dental and Craniofacial Research
Additional information about NIDCR career development programs can be found at
http://www.nidcr.nih.gov/resarch/career.htm.
Dr. James A. Lipton
Assistant Director for Training and Career Development
Natcher Building, Room 4AN.18J
Bethesda, MD  20892-6402
Telephone:  (301) 594-2618
FAX:  (301) 480-8319
Email:  liptonj@de45.nidcr.nih.gov

National Institute of Diabetes and Digestive and Kidney Diseases
Ronald Margolis, Ph.D.
Division of Diabetes, Endocrinology, and Metabolic Diseases
45 Center Drive, Room 5AN-12J, MSC 6600
Bethesda, MD 20892-6600
Telephone: (301) 594-8819
FAX: (301) 480-3503
Email: margolisr@extra.niddk.nih.gov

Charles Rodgers, Ph.D.
Division of Kidney, Urologic, and Hematologic Diseases
45 Center Drive, Room 6AS-19J MSC 6600
Bethesda, MD  20892-6600
Telephone:  (301) 594-7717
FAX:  (301) 480-3510
Email:  rodgersc@ep.niddk.nih.gov

Judith Podskalny, Ph.D.
Division of Digestive Diseases and Nutrition
45 Center Drive, Room 6AN-12E, MSC 6600
Bethesda, MD  20892-6600
Telephone:  (301) 594-8876
FAX:  (301) 480-8300
Email:  podskalnyj@ep.niddk.nih.gov

National Institute on Drug Abuse
Andrea Baruchin, Ph.D.
Office of Science Policy and Communications
6001 Executive Boulevard, Room 5230
Bethesda, Maryland 20892-9591
Telephone: (301) 443-6071
FAX: (301) 443-6277
email: ab47j@nih.gov

Lucinda Miner, Ph.D.
Office of Science Policy and Communications
6001 Executive Boulevard, Room 5230
Bethesda, Maryland 20892-9591
Telephone: (301) 443-6071
FAX: (301) 443-6277
Email: cm171w@nih.gov

Charles W. Sharp, Ph.D.
Division of Basic Research
6001 Executive Boulevard, Room 4271
Rockville, MD  20857
Telephone:  (301) 443-1887
FAX:  (301) 594-6043
Email:  cs107m@nih.gov

Arthur Horton, Ed.D.
Division of Clinical Research
6001 Executive Boulevard, Room 4237
Rockville, MD  20857
Telephone:  (301) 443-4060
FAX:  (301) 443-2317
Email:  ah61x@nih.gov

Ann Blanken
Division of Epidemiology and Prevention Research
6001 Executive Boulevard, Room 5146
Rockville, MD  20857
Telephone:  (301) 443-6543
FAX:  (301) 443-9847
Email:  ab108v@nih.gov

Jamie Biswas, Ph.D.
Medications Development Division
6001 Executive Boulevard, Room 4109
Rockville, MD  20857
Telephone:  (301) 443-5280
FAX:  (301) 443-2599
Email:  jb168r@nih.gov

National Institute of Environmental Health Sciences
Dr. Carol Shreffler
Division of Extramural Research and Training
P. O. Box 12233 MD EC-23
Research Triangle Park, NC  27709
Telephone:  (919) 541-1445
FAX:  (919) 541-5064
Email:  shreffl1@niehs.nih.gov

National Eye Institute
Additional information about NEI career development programs can be found at
http://www.nei.nih.gov/funding/special.htm#training.

Maria Y. Giovanni, Ph.D.
National Eye Institute, NIH
EPS Suite 350
6120 Executive Blvd.  MSC  7164
Bethesda, MD  20892-7164
301-496-0484
301-402-0528
Email:  myg@nei.nih.gov

National Institute of General Medical Sciences
The National Institute of General Medical Sciences (NIGMS) will accept
applications for the Mentored Clinical Scientist Development Award (K08) in
the areas of anesthesiology, clinical pharmacology, and trauma and burn injury
research.  NIGMS will offer the K08 award to support the development of
academic physicians (or individuals with comparable clinical training) into
scientists capable of outstanding laboratory research, clinical research, or a
combination of both.  The candidate must be in a tenure track or equivalent
position at the time of award. The application should clearly indicate that
the candidate has sufficient resources available to perform the research. Such
resources may be provided by the mentor, the institution, or both.  If
significant support is derived from the mentor, then the application should
indicate how the candidate will ultimately gain independence.  The candidate
must provide evidence of having a broad understanding of the theoretical
aspects of basic or clinical science, attained prior to or during the course
of this award, along with a defined plan for career development.  Applicants
are strongly encouraged to contact one of the following early in the
preparation of an application:

Alison E. Cole, Ph.D.
Anesthesiology Program
Division of Pharmacology, Physiology and Biological Chemistry
45 Center Drive, Room 2AS-49K, MSC 6200
Bethesda, MD 20892-6200
Telephone: (301) 594-1826
FAX: (301) 480-2802
Email: colea@nigms.nih.gov

Rochelle M. Long, Ph.D.
Clinical Pharmacology Program
Division of Pharmacology, Physiology, and Biological Chemistry
45 Center Drive, Room 2AS-49A, MSC 6200
Bethesda, MD 20892-6200
Telephone: (301) 594-1826
FAX: (301) 480-2802
Email: longr@nigms.nih.gov

Scott D. Somers, Ph.D.
Trauma and Burn Injury Program
Division of Pharmacology, Physiology and Biological Chemistry
45 Center Drive, Room 2AS-49J, MSC 6200
Bethesda, MD 20892-6200
Telephone: (301) 594-5560
FAX: (301) 480-2802
Email: somerss@nigms.nih.gov

For questions about grants management, contact:
Toni Holland
Grants Management Officer
45 Center Drive, Room 2AN.50B, MSC 6200
Bethesda, MD 20892-6200
Telephone: (301) 594-5132
FAX: (301) 480-3423
Email: hollandt@nigms.nih.gov

National Heart, Lung, and Blood Institute
Beth Schucker, M.A.
Division of Heart and Vascular Diseases
6701 Rockledge Drive, Room 9206
Bethesda, MD 20892-7940
Telephone: (301) 435-0535
FAX: (301) 480-1454
E-mail: schuckeb@nih.gov

National Institute of Mental Health
NIMH strongly encourages prospective applicants and grantees to visit the NIMH
Research Training and Career Development Programs Website
http://www.nimh.nih.gov/grants/training.cfm to obtain information about
policies, program priorities and program staff contacts.  Specific information
about NIMH policy for career awards, salary and research support, etc., can be
found in the following document: "NIMH Policy Update for Career Awards (K-
Series)" which will periodically be updated in the Research Training and
Career Development Website.

Henry Khachaturian, Ph.D.
Office of Science Policy and Program Planning
National Institute of Mental Health
6001 Executive Boulevard
Room 8208, MSC 9667
Bethesda, Maryland 20892
Phone:  (301) 443-4335
FAX:  (301) 443-3225
E-mail:  hk11b@nih.gov

Della Hann, Ph.D.
Division of Mental Disorders, Behavioral Research and AIDS
National Institute of Mental Health
Room 6217, MSC 9621
6001 Executive Boulevard
Bethesda, Maryland 20892
Telephone:  (301) 443-9700
Fax:  (301) 480-6000
E-mail:  dhann@mail.nih.gov

Walter Goldschmidts, Ph.D.
Division of Neuroscience and Basic Behavioral Science
National Institute of Mental Health
6001 Executive Boulevard, Room 7196, MSC 9645
Bethesda, Maryland 20892
Telephone: (301) 443-3563
Fax: (301) 443-1731
Email:  wgoldsch@mail.nih.gov

Enid Light, Ph.D.
Division of Services and Intervention Research
National Institute of Mental Health
6001 Executive Boulevard, Room 7160, MSC 9635
Bethesda, Maryland 20892
Telephone: (301) 443-1185
Fax: (301) 443-4045
E-mail: elight@mail.nih.gov

National Institute of Neurological Disorders and Stroke
NINDS Training and Career Development Officer
National Institute of Neurological Disorders and Stroke
6001 Executive Boulevard, Room 2154, MSC 9531
Bethesda, MD 20892 (for courier: Rockville, MD 20852)
Phone: (301) 496-4188
FAX: (301) 594-5929
Email: NINDSTrainingOffice@ninds.nih.gov

National Institute of Nursing Research
NINR limits the length of the K23 award to a 3-year period and generally
considers career development applications only from doctorally prepared,
registered nurses. Potential applicants are strongly encouraged to contact the
Program Director responsible for their research area as listed on the NINR
website.  Additional information about NINR funding mechanisms is available
from http://www.ninr.nih.gov/

Dr. Nell Armstrong
Office of Extramural Programs
National Institute of Nursing Research
Building 45, Rm. 3AN-12
45 Center Drive MSC 6300
Bethesda, MD  20892-6300
Telephone:  301-594-5973
Fax:  301-480-8260
E-mail:  nell_armstrong@nih.gov

National Center for Complementary and Alternative Medicine
Additional information about CAM research and training programs may be found
on the NCCAM website at http://altmed.od.nih.gov/

Neal West, Ph.D.
Extramural Research Programs Officer
Building 31, Room 5B-58
Bethesda, MD  20892
Telephone:  301-435-5042
FAX:  301-402-4741
E-mail:  westn@od.nih.gov

National Center for Research Resources
NCRR will accept applications for the K23 award from individuals with a M.D.,
D.D.S., or an equivalent degree.  Candidates must also meet additional
requirements related to their relationship to one of NCRRþs existing General
Clinical Research Centers (GCRC).  Additional information about eligibility
and assignment of K23 applications to NCRR, can be found at 
http://www.ncrr.nih.gov/clinical/cr_crcd.asp and refer to Clinical
Research: Other Grant Programs, Mentored Patient-Oriented Research Career
Development Award (K23).

Applicants who intend to use the research infrastructure of a GCRC, and wish
to designate NCRR for primary assignment in response to this program
announcement, should submit a cover letter with their application which states
this assignment preference.

David Wilde, M.D., Ph.D.
Clinical Research
National Center for Research Resources
6705 Rockledge Dr. Room 6130 MSC 7965
Bethesda, Maryland 20892-7965
Telephone:  (301) 435-0799
FAX:  (301) 480-3661
Email: dw171w@nih.gov

AUTHORITY AND REGULATIONS

This program is described in the Catalog of Federal Domestic Assistance Nos.
93. 855 and 93.856.  Awards are made under the authority of title III, Section
301 of the PHS Act as amended.  The Code of Federal Regulations, Title 42 Part
52 and Title 45 Part 74, are applicable to this program.  This program is not
subject to the intergovernmental review requirements of Executive Order 12372
to Health Systems Agency review.

The PHS strongly encourages all grant and contract recipients to provide a
smoke-free workplace and promote the non-use of all tobacco products.  In
addition, Public Law 103-227, the Pro-Children Act of 1994, prohibits smoking
in certain facilities (or in some cases, any portion of a facility) in which
regular or routine education, library, day care, health care or early
childhood development services are provided to children.  This is consistent
with the PHS mission to protect and advance the physical and mental health of
the American people.

Weekly TOC for this Announcement
NIH Funding Opportunities and Notices

	Office of Extramural Research (OER)			National Institutes of Health (NIH) 9000 Rockville Pike Bethesda, Maryland 20892			Department of Health and Human Services (HHS)
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