DEPARTMENT OF HEALTH. EDUCATION. AND WELFARE

February 18, 1982

DonaldW.Denny
Director of Organ Procurement
I)niverrlty of Pittrburgh
School of Medicine
954 Scaife Hall
PittBburgh, PA 13261

Dear Mr. Denny:

The crux of the Daiform Determination of Death Act ir the rcientific
promdutier u8ed to determine "total brain death". The law is wirely
silent on thwe techaiqwu.

Since your vilrit here we heve not been idle.  I have prepared a
dscirion memomndwm in reference to liver tranrplantation in children
and it may well be that after con8ultatione next week we may go 80
far a8 to have a e~%semus conference on liver tran8plantation usiug
eyclorporin A a8 an imuno ruppre8aant.

There are Will unanswered quertiona about cycloqorin A having to do
with its availability, ite ultimate safety, end fart tracking it
through FDA.

T&e bottom line in a11 of there dieeu8SiOn8 here he8 been what can
thie office do to help tramplanters obtain neaurary organs in a
viable state md how can we aid thir protesr and prevent abuse of
the prOC886 at the 8&M time.

f would appreciate a call from you 8ome time 8t your convenience 80
that 3a might di8curo lome of your thought8 on organ procurement that
will natUtdly come up a8 Ye get deeper iat0 our di8cu88ion8 Of funding
trarrplmtation of the liver and achieving a lower rejection rate in
renal transplantati&.

Sincerely youra,

C. Everett Koop, H.D.
Surgeon Goneral

  C
LB OP




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:saj:2/18/82

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