Laboratory of Genetics and Physiology : NIDDK

Scientific Programs

Contact Details

Lothar Hennighausen
National Institute of Diabetes and Digestive and Kidney Diseases
National Institutes of Health
Bldg. 8, Rm. 101
Bethesda, Maryland 20892

Laboratory of Genetics and Physiology

Laboratory of Genetics and Physiology Group picture

The Laboratory of Genetics and Physiology (LGP) explores genetic circuitry in organ development, physiology and disease. The emphasis is on intellectual and medical problems related to the role of cytokines with a focus on the JAK/STAT pathway. Using traditional and cell-specific gene knock-out mice, researchers in LGP have discovered that the transcription factors STAT5a/b are essential for the development and function of several distinct cell systems. 

Current research is aimed towards an understanding of the genetic logic underlying the cell specific functions of STAT5 during normal hematopoiesis and leukemias, liver function and in mammary development and cancer.  In addition, researchers in LGP use mouse genetics to decipher the role of Notch signaling in the specification of cell lineages within the mammary gland.

General inquiries may be addressed to: Office of Communications & Public Liaison
Building 31. Rm 9A06
31 Center Drive, MSC 2560
Bethesda, MD 20892-2560
For information about NIDDK programs: 301.496.3583

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