Figure 1. Model illustrating the effects of the structural chromatin-binding proteins H1, HMGN1, and HMGN2 on the levels of specific histone modifications. These proteins affect the levels of histone modifications by altering the dynamic equilibrium between the enzymes that continuously add or remove chemical tags, such as acetyl or phosphate groups, to histone tails. N2, HMGN2; S10, serine 10; K14, lysine 14; S10p, phosphorylated S10; H1, histone 1; K14ac, acetylated K14; HAT, histone acetylase; HDAC, histone deacetylase.