Lipids and the Pathophysiology of Obesity
Renaissance Marriott Hotel
Washington DC
May 10-11, 2004
Summary
In the midst of an epidemic of obesity, with many likely and poorly understood causes, NIH has developed a multi-pronged attack on the problem. This workshop supported by NIDDK , NHLBI , NIA , NICHD , NIGMS, and ODS will focus attention on how alterations in lipid metabolism and signaling impact the development of obesity and its complications. Lipids, whether derived from the diet or from cellular metabolic activities, play a major role in overall energy balance, and any number of alterations in lipid metabolism may contribute to the disease state. Since lipids are used as sources of fuel for energy production, as structural elements, and as signaling molecules, there are many different levels at which further understanding is needed. For example, little is known about events in specific cells and tissues that lead to greater fat accumulation, alterations in fat deposition, generation of harmful metabolites, and development of specific cellular injuries. This workshop will attempt to define the current state-of-the-art and provide a blueprint for development of new initiatives designed to address the role of lipid metabolism in the obesity epidemic. The invited speakers and attendees will be asked to help provide this blueprint through a variety of inputs, including platform presentations, posters, and discussions.
Speakers
Richard Bergman, PhD
University of Southern California
Los Angeles, CA
David Bernlohr, PhD
University of Minnesota
Minneapolis, MN
Sonia Caprio, MD
Yale University School of Medicine
New Haven, CT
Roger D. Cone, PhD
Oregon Health Science University
Portland, OR
Edward A. Dennis, PhD
University of California, San Diego
La Jolla, CA
Ronald M. Evans, PhD
The Salk Institute for Biological Studies
La Jolla, CA
Jeffrey Flier, MD
Beth Israel Deaconess Medical Center
Boston, MA
Christopher R. Glass, MD
University of California, San Diego
School of Medicine
La Jolla, CA
Jonathon M. Graff, MD, PhD
University of Texas
Southwestern Medical Center
Dallas, TX
Barbara Kahn, MD
Beth Israel Deaconess Medical Center
Boston, MA
Daniel P. Kelley, MD
Washington University
School of Medicine
St. Louis, MO
David Kelley, MD
University of Pittsburgh
Pittsburgh, PA
Ahmed Kiessebah, MD
Medical College of Wisconsin
Milwaukee, WI
|
Valerie Large, PhD
INSERM
Lyon, France
Mitchell A. Lazar, MD, PhD
University of Pennsylvania
School of Medicine
Philadelphia, PA
David J. Mangelsdorf, PhD
University of Texas
Southwestern Medical Center
Dallas, TX
Robert C. Murphy, PhD
National Jewish Medical and Research Center
Denver, CO
Jerry Nadler, MD
University of Virginia
Charlottesville, VA
Luciano Rossetti, MD
Albert Einstein College of Medicine
Bronx, NY
Neil Ruderman, MD
Boston Medical Center
Boston, MA
Jean E. Schaffer, PhD
Washington University
School of Medicine
St. Louis, MO
Bruce M. Spiegelman, PhD
Harvard Medical School
Boston, MA
Richard Weindruch, PhD
University of Wisconsin VA Hospital
Madison, WI |
Agenda
MAY 10, 2004
Auditorium (Meeting room level)
7:00-8:00
Continental Breakfast and Registration
8:00-8:10
Introductions and opening remarks
8:10-8:50
Plenary 1: Ron Evans
Metabolic communication between muscle and fat:
You say hello I say goodbye
Session I: Lipids and roles in obesity
8:50-9:15
Richard Bergman
Regional adiposity and insulin resistance
9:15-9:40
Luciano Rossetti
Hypothalamic sensing of nutrients plays a pivotal
role in the regulation of liver glucose homeostasis
9:40-10:05
Mitchell Lazar
Update on Resistin
10:05-10:30
Break
10:30-10:55
Jonathan Graff
Invertebrate models of fat storage
10:55-11:20
David Bernlohr
Intracellular fatty acid trafficking and the metabolic syndrome
11:20-11:40
HOT TOPIC
Daniele Piomelli
Oleylethanolamide: an endogenous PPAR-alpha ligand involved in the control of satiety and body weigh t
11:40-1:00
Lunch (on your own)
1:00-1:40
Plenary 2: Edward Dennis (Co-Chair)
Lipidomics and lipid signaling in the macrophage:
The Lipid Maps Initiative
Session II: Lipids and biological signaling
1:40-2:05
David Mangelsdorf (Co-Chair)
The role of nuclear receptors as lipid sensors
2:05-2:30
Neil Ruderman
AMPK, Malonyl CoA and Obesity
2:30-2:55
Robert Murphy
Qualitative and quantitative analysis of lipids by mass spectrometry
2:55-3:10
Break
3:10-3:35
Valerie Large
Regulation, expression and activity of hormone-sensitive lipase in adipose tissue of obese subjects
3:35-4:00
Barbara Kahn
AMP Kinase: Sensor of metabolic stress
4:00-4:20
HOT TOPIC
Bruce Kristal
Biomarkers for caloric intake in rats
4:30-6:30
Poster session and reception
Congressional B (ballroom level)
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Page last updated: November 25, 2008
