| Agent Name |
1,1,1,2-Tetrachloro-2,2-difluoroethane |
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| CAS Number |
76-11-9 |
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| Formula |
C2-Cl4-F2 |
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| Major Category |
Solvents |
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| Synonyms |
1,1-Difluoro-1,2,2,2-tetrachloroethane; 1,1-Difluoroperchloroethane; 2,2-Difluoro-1,1,1,2-tetrachloroethane; 2,2-Difluorotetrachloroethane; CFC 112a; Ethane, 1,1-difluoro-1,2,2,2-tetrachloro-; F 112a; Fluorocarbon 112a; Halocarbon 112a; R 112a; Refrigerant 112a; [ChemIDplus] |
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| Category |
Chlorofluorocarbons |
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| Description |
Colorless solid with a slight, ether-like odor. [Note: A liquid above 105 degrees F]; [NIOSH] |
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| Sources/Uses |
CFC-112a has been used as a refrigerant. [ACGIH] "Use in dry cleaning industry; in polymer & plastics industry as blowing or foaming agent; as solvent extractor for separation & purification of biological material; as a dye solvent to give brighter colors and to detect surface cracks or defects in metals; as a corrosion inhibitor."; [HSDB] |
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| Comments |
Rats exposed to 10,000 ppm for 2 hours show signs of intoxication. At 20,000 to 30,000 ppm, all rats die within 1.5 to 2 hours. There are signs of kidney and liver injury, but no signs of pulmonary injury. [ACGIH] See "CHLOROFLUOROCARBONS"; |
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| Restricted |
See CHLOROFLUOROCARBONS |
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| Exposure Assessment |
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| Skin Designation (ACGIH) |
No |
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| TLV (ACGIH) |
100 ppm |
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| PEL (OSHA) |
500 ppm |
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| MAK |
200 ppm |
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| IDLH (NIOSH) |
2000 ppm |
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| Excerpts from Documentation for IDLHs |
Other animal data: Rats exposed to 10,000 ppm for 1.5 to 2 hours showed slight signs of intoxication but no loss of reflexes, while a concentration of 20,000 to 30,000 ppm was fatal in 1.0 to 2.5 hours [Greenberg and Lester 1950]. |
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| Vapor Pressure |
60 mm Hg |
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| Lethal Concentration |
LCLo (rats) = 20,000 ppm/30 min |
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| Adverse Effects |
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| Neurotoxin |
CNS Solvent Syndrome |
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| Hepatotoxin |
Hepatotoxin, Secondary |
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| Links to Other NLM Databases |
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| Health Studies |
Human Health Effects from Hazardous Substances Data Bank: 1,1,1,2-TETRACHLORO-2,2-DIFLUOROETHANE
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