| Agent Name |
p-Nitroaniline |
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| CAS Number |
100-01-6 |
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| Formula |
C6-H6-N2-O2 |
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| Major Category |
Nitrogen Compounds |
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| Synonyms |
1-Amino-4-nitrobenzene; 4-Nitraniline; 4-Nitroaniline; 4-Nitrobenzenamine; Aniline, 4-nitro-; Aniline, p-nitro-; Azoamine Red ZH; Azofix Red GG Salt; Azoic Diazo Component 37; Benzenamine, 4-nitro-; C.I. 37035; C.I. Azoic Diazo Component 37; C.I. Developer 17; CI 37035; CI Azoic Diazo Component 37; CI Developer 17; Developer P; Devol Red GG; Diazo Fast Red GG; Fast Red 2G Base; Fast Red 2G Salt; Fast Red Base 2J; Fast Red Base GG; Fast Red GG Base; Fast Red GG Salt; Fast Red MP Base; Fast Red P Base; Fast Red P Salt; Fast Red Salt 2J; Fast Red Salt GG; Naphtoelan Red GG Base; Nitrazol CF Extra; PNA; PNA (VAN); Red 2G Base; Shinnippon Fast Red GG Base; p-Aminonitrobenzene; p-Nitraniline; p-Nitroanilina [Polish]; p-Nitroaniline; p-Nitrophenylamine; para-Aminonitrobenzene; para-Nitroaniline; [ChemIDplus] UN1661 |
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| Category |
Nitros, Aromatic |
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| Description |
Bright yellow, crystalline powder with a slight ammonia-like odor; [NIOSH] |
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| Sources/Uses |
Used in the production of dyes, antioxidants, gasoline gum inhibitors, and corrosion inhibitors; [ACGIH] |
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| Comments |
Can cause severe methemoglobinemia in the workplace; Chronic exposure can cause anemia, jaundice, and liver injury; Listed in a table of "Industrial Chemicals for Which Methemoglobin Formation is the Principal Cause of Toxicity"; [ACGIH] A mild eye irritant; May induce methemoglobinemia; [ICSC] |
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| Exposure Assessment |
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| BEI |
Methemoglobin in blood = 1.5% of hemoglobin during or at end of shift. [ACGIH] |
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| Skin Designation (ACGIH) |
Yes |
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| TLV (ACGIH) |
3 mg/m3 |
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| PEL (OSHA) |
6 mg/m3 |
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| IDLH (NIOSH) |
300 mg/m3 |
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| Excerpts from Documentation for IDLHs |
Basis for original (SCP) IDLH: The chosen IDLH (300 mg/m3 or 50 ppm) is based on an analogy with aniline and the statement by AIHA [1955] that 50 to 100 ppm aniline can probably be tolerated for 1 hour. Although the IDLH chosen for aniline was 100 ppm, the IDLH of 50 ppm (300 mg/m3) chosen for p�nitroaniline is reasonable because Von Oettingen [1941] stated that p�nitroaniline is more toxic than aniline. . . . Human data: None relevant for use in determining the revised IDLH |
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| Vapor Pressure |
0.004 mm Hg |
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| Explanatory Notes |
Flash point = 199 deg C; |
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| Flammability (NFPA) |
1: must be preheated |
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| Adverse Effects |
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| Methemoglobinemia |
Methemoglobinemia, Primary |
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| Hepatotoxin |
Hepatotoxin, Secondary |
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| Links to Other NLM Databases |
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| Health Studies |
Human Health Effects from Hazardous Substances Data Bank: 4-NITROANILINE
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