| Agent Name |
m-Dinitrobenzene |
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| CAS Number |
99-65-0 |
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| Formula |
C6-H4-N2-O4 |
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| Major Category |
Nitrogen Compounds |
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| Synonyms |
1,3-Dinitrobenzene; 1,3-Dinitrobenzol; 2,4-Dinitrobenzene; Benzene, 1,3-dinitro-; Benzene, m-dinitro-; Dinitrobenzene; Dwunitrobenzen [Polish]; m-DNB; m-Dinitrobenzene; meta-Dinitrobenzene; [ChemIDplus] UN1597 |
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| Category |
Nitros, Aromatic |
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| Description |
Pale-white or yellow, crystalline solid; [NIOSH] |
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| Sources/Uses |
Usually manufactured as a mixture of 3 isomers, DNB is used to make dyes, explosives, celluloids, and organic chemicals; [ACGIH] |
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| Comments |
Methemoglobinemia, liver injury, and visual impairment have been reported in exposed workers. Listed in table of "Industrial Chemicals for Which Methemoglobin Formation is the Principal Cause of Toxicity"; [ACGIH] m-Dinitrobenzene was elliminated from in vitro testing after little response was detected, even at high concentrations. [French CL et al. Potency ranking of methemoglobin-forming agents. J Appl Toxicol. 15(3):167-74 (1995).]; An eye and respiratory tract irritant; Can induce methemoglobinemia and have effects on the liver; [ICSC] |
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| Reference Link |
ATSDR - ToxFAQs - 1,3-Dinitrobenzene and 1,3,5-Trinitrobenzene |
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| Exposure Assessment |
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| BEI |
Methemoglobin in blood = 1.5% of hemoglobin during or at end of shift. [ACGIH] |
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| Skin Designation (ACGIH) |
Yes |
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| TLV (ACGIH) |
1 mg/m3 |
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| PEL (OSHA) |
1 mg/m3 |
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| IDLH (NIOSH) |
50 mg/m3 |
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| Excerpts from Documentation for IDLHs |
Human data: The probable lethal oral dose has been reported to be 2 grams [Deichmann and Gerarde 1969]. [Note: An oral dose of 2 grams is equivalent to a worker being exposed to about 1,300 mg/m3 for 30 minutes, assuming a breathing rate of 50 liters per minute and 100% absorption.] |
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| Vapor Pressure |
0.0002 mm Hg |
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| Explanatory Notes |
Flash point = 302 deg F; |
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| Adverse Effects |
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| Methemoglobinemia |
Methemoglobinemia, Primary |
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| Hepatotoxin |
Hepatotoxin, Secondary |
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| Links to Other NLM Databases |
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| Health Studies |
Human Health Effects from Hazardous Substances Data Bank: 1,3-DINITROBENZENE
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