| Agent Name |
18-Crown-6 |
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| CAS Number |
17455-13-9 |
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| Formula |
C12-H24-O6 |
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| Major Category |
Other Classes |
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| Synonyms |
1,4,7,10,13,16-Hexanoxacyclooctadecane; 1,4,7,10,13,16-Hexaoxacyclooctadecane; 18-Crown-6; Ethylene oxide cyclic hexamer; [ChemIDplus] |
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| Category |
Other Organic Compounds |
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| Description |
Clear, odorless, hygroscopic liquid soluble in water and most organic solvents; [Ullmann] White crystals; [MSDSonline] |
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| Sources/Uses |
Drug/ Therapeutic Agent; [ChemIDplus] Used as complexing agents with ammonium ions and metal ions (alkali and alkaline-earth metals); Used as catalysts to make organic chemicals; [Ullmann] |
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| Comments |
If absorbed, can cause electrolyte imbalance affecting the CNS; Signs of intoxication include hyperventilation, tremor, incoordination, and CNS depression; May damage the skin and eyes; LD50 (mouse) by ingestion is 0.7 g/kg; LD50 (rabbit) by skin absorption is 200 mg/kg; [Ullmann] Toxic by ingestion; A skin, eye, and respiratory tract irritant; Oral LD50 (rat) = 525 mg/kg; Dermal LDLo (rat) = 7000 mg/kg; High-dose feeding causes seizures, weight loss, and liver injury in experimental animals; [MSDSonline] |
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| Exposure Assessment |
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| Vapor Pressure |
6.67 x 10 -05 mm Hg |
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| Explanatory Notes |
mp = -38 deg C; bp = 116 deg C; [Ullmann] mp = 39-40 deg C; [MSDSonline] |
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| Flammability (NFPA) |
1: must be preheated |
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| Adverse Effects |
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| Neurotoxin |
Other CNS Neurotoxin |
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| Hepatotoxin |
Hepatotoxin, Secondary |
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| Links to Other NLM Databases |
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