| Agent Name |
MDA |
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| Alternative Name |
4,4'-Methylenedianiline |
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| CAS Number |
101-77-9 |
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| Formula |
C13-H14-N2 |
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| Major Category |
Nitrogen Compounds |
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| Synonyms |
4,4'-Diaminodiphenylmethan [German]; 4,4'-Diaminodiphenylmethane; 4,4'-Dimethylenediamine; 4,4'-Diphenylmethanediamine; 4,4'-Methylenebis(benzeneamine); 4,4'-Methylenebisaniline; 4,4'-Methylenedianiline; 4-(4-Aminobenzyl)aniline; Ancamine TL; Aniline, 4,4'-methylenedi-; Araldite hardener 972; Avaldite HT 972; Benzenamine, 4,4'-methylenebis-; Bis(4-aminophenyl)methane; Bis(p-aminophenyl)methane; Bis-p-aminofenylmethan [Czech]; Curithane; Dadpm; Di-(4-aminophenyl)methane; Diaminodiphenylmethane; Dianilinemethane; Dianilinomethane; Epicure DDM; Epikure DDM; HT 972; Jeffamine AP-20; MDA; Methylenebis(aniline); Methylenedianiline; Methylenedianiline (VAN); Sumicure M; Tonox; p,p'-Diaminodifenylmethan [Czech]; p,p'-Diaminodiphenylmethane; p,p'-Methylenedianiline; p-Toluidine, alpha-(p-aminophenyl)-; [ChemIDplus] UN2651 |
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| Category |
Amines, Aromatic |
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| Description |
Pale-brown, crystalline solid with a faint, amine-like odor; [NIOSH] |
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| Sources/Uses |
Used as a chemical intermediate, lab analytic agent, and monomer for polyamide and polymide resins; [HSDB] Used primarily in the manufacture of rubber and plastics; used as an epoxy resin hardener in the following applications: glues, paints, inks, polyvinylchloride products, dental bonding agents, and microelectronic encapsulations; [Marks, p. 269] |
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| Comments |
Has caused liver injury after occupational exposure; "Some of the most commonly used curing agents in the advanced composite industry are the aromatic amines. Two of the most common are 4,4'-methylene-dianiline (MDA) and 4,4'-sulfonyldianiline (DDS). Like the epoxies, these compounds have a very low vapor pressure and usually do not present an airborne hazard unless in a mixture that is sprayed or cured at high temperatures. However, potential for dermal exposure is frequently high. The aromatic amines may permeate many of the commonly used protective gloves and thus may be particularly difficult to protect against." [OSHA Technical Manual: Advanced Composites] A rare cause of occupational allergic contact dermatitis; [Marks, p. 268-70] Merck Index #2980; A potential skin sensitizer and liver toxicant; [ICSC] |
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| Restricted |
Carcinogen--See 29 CFR 1910.1050 |
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| Reference Link |
ATSDR ToxFAQs - MDA |
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| Exposure Assessment |
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| Skin Designation (ACGIH) |
Yes |
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| TLV (ACGIH) |
0.1 ppm |
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| PEL (OSHA) |
0.01 ppm, STEL(OSHA) = 0.1 ppm |
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| Vapor Pressure |
2 x 10 -07 mm Hg |
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| Explanatory Notes |
Flash point = 220 deg C; |
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| Half Life |
Plasma: 13 hours; urine: 7 hours; [TDR, p. 872] |
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| Reference Link |
Occupational dermatitis from exposure to polyurethane chemicals |
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| Flammability (NFPA) |
1: must be preheated |
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| Adverse Effects |
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| Skin Sensitizer |
Yes |
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| Hepatotoxin |
Hepatotoxin, Primary |
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| IARC Carcinogen |
Possible Carcinogen |
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| Links to Other NLM Databases |
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| Health Studies |
Human Health Effects from Hazardous Substances Data Bank: 4,4'-DIAMINODIPHENYLMETHANE
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