Agent Name |
5-Nitro-2-toluidine |
Alternative Name |
Nitro-o-toluidine |
CAS Number |
99-55-8 |
Formula |
C7-H8-N2-O2 |
Major Category |
Nitrogen Compounds |
Synonyms |
AI3-01557; Amarthol Fast Scarlet G Base; Amarthol Fast Scarlet G Salt; 2-Amino-4-nitrotoluene; Azoene Fast Scarlet GC Base; Azoene Fast Scarlet GC Salt; Azofix Scarlet G Salt; Azogene Fast Scarlet G; Benzenamine, 2-methyl-5-nitro-; CI Azoic Diazo Component 12; CI 37105; Dainichi Fast Scarlet G Base; Daito Scarlet Base G; Devol Scarlet B; Devol Scarlet G Salt; Diabase Scarlet G; Diazo Fast Scarlet G; Fast Red SG Base; Fast Scarlet G; Fast Scarlet G Base; Fast Scarlet Base J; Fast Scarlet T Base; Fast Scarlet M4NT Base; Fast Scarlet GC Base; Fast Scarlet G Salt; Fast Scarlet J Salt; Hiltonil Fast Scarlet G Base; Hiltonil Fast Scarlet GC Base; Hiltonil Fast Scarlet G Salt; Kayaku Scarlet G Base; Lake Scarlet G Base; Lithosol Orange R Base; 2-Methyl-5-nitroaniline; 6-Methyl-3-nitroaniline; 2-Methyl-5-nitro-benzenamine; Mitsui Scarlet G Base; Naphthanil Scarlet G Base; Naphtoelan Fast Scarlet G Base; Naphtoelan Fast Scarlet G Salt; 4-Nitro-2-aminotoluene; 3-Nitro-6-methylaniline; PNOT; Scarlet G Base; Scarlet Base Ciba II; Scarlet Base IRGA II; Scarlet Base NSP Sugai Fast Scarlet G Base; Symulon Scarlet G Base; o-Toluidine, 5-nitro-; Nitro-o-toluidine; [HSDB] 4-Nitro-2-aminotoluene; [Guide to Occupational Exposure Values, 2002] UN2660 |
Category |
Nitros, Aromatic |
Description |
Yellow crystals; [ACGIH] |
Sources/Uses |
Workers are exposed during production or handling of more than 35 commercial dyes (orange or red) of which 5-nitro-o-toluidine is the major component; [ACGIH] |
Comments |
Several Japanese workers were admitted to the hospital with severe liver damage after handling repeatedly (12-20 times) 5-nitro-o-toluidine for 4-5 hours at a time. Workers had scooped the powder by hand while wearing respirators. [Gut 2002 Feb;50(2):266-70] Methemoglobinemia is a potential adverse effect after exposure to this agent. [HSDB] |
Reference Link |
Liver dysfunction among workers handling 5-nitro-o-toluidine |
Exposure Assessment |
Skin Designation (ACGIH) |
No |
TLV (ACGIH) |
1 mg/m3, inhalable fraction |
Vapor Pressure |
0.000975 mm Hg |
Adverse Effects |
Methemoglobinemia |
Methemoglobinemia, Secondary |
Hepatotoxin |
Hepatotoxin, Primary |
IARC Carcinogen |
Not Classifiable |
Links to Other NLM Databases |
Health Studies |
Human Health Effects from Hazardous Substances Data Bank: 5-NITRO-O-TOLUIDINE
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