| Agent Name |
Hexachlorophene |
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| CAS Number |
70-30-4 |
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| Formula |
C13-H6-Cl6-O2 |
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| Major Category |
Other Uses |
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| Synonyms |
2,2',3,3',5,5'-Hexachloro-6,6'-dihydroxydiphenylmethane; 2,2'-Dihydroxy-3,3',5,5',6,6'-hexachlorodiphenylmethane; 2,2'-Dihydroxy-3,5,6,3',5',6'-hexachlorodiphenylmethane; 2,2'-Methylenebis(3,4,6-trichlorophenol); AT 7; Acigena; Almederm; Armohex; At-17; B & b Flea Kontroller for Dogs Only; B 32 (VAN); B32; Bilevon; Bis(2-hydroxy-3,5,6-trichlorophenyl)methane; Bis(3,5,6-trichloro-2-hydroxyphenyl)methane; Bis-2,3,5-trichloro-6-hydroxyfenylmethan [Czech]; Blockade Anti Bacterial Finish; Brevity Blue Liquid Bacteriostatic Scouring Cream; Brevity Blue Liquid Sanitizing Scouring Cream; Compound G-11; Cotofilm; Dermadex; Distodin; En-Viron D Concentrated Phenolic Disinfectant; Enditch Pet Shampoo; Esaclorofene [DCIT]; Exofene; Fesia-sin; Fomac; Fostril; G-11; G-Eleven; G-II; Gamophen; Gamophene; Germa-medica; HCP; Hexabalm; Hexachlorofen; Hexachlorofen [Czech]; Hexachlorophen; Hexachlorophene; Hexachlorophenum [INN-Latin]; Hexaclorofeno [INN-Spanish]; Hexafen; Hexaphene-LV; Hexide; Hexophene; Hexosan; Hilo Cat Flea Powder; Hilo Flea Powder; Methane, bis(2,3,5-trichloro-6-hydroxyphenyl)-; Nabac; Nabac 25 EC; Neosept V; Pedigree Dog Shampoo Bar; Phenol, 2,2'-methylenebis(3,4,6-trichloro)-; Phenol, 2,2'-methylenebis(3,4,6-trichloro-; Phenol, 2,2'-methylenebis(3,5,6-trichloro-; Phisodan; Ritosept; Septisol; Septofen; Solu-Heks; Staphene O; Ster-Zac; Steral; Steraskin; Surgi-Cen; Surgi-cin; Surofene; Tersaseptic; Thera-Groom Pet Shampoo for Dogs for Veterinary Use Only; Trichlorophene; Trisophen; Turgex; pHisoHex; [ChemIDplus] UN2875 |
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| Category |
Preservatives/Disinfectants |
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| Description |
White to light tan, crystalline powder; [HSDB] |
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| Sources/Uses |
Used as an antibacterial agent, disinfectant, fungicide, and acaricide; [HSDB] |
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| Comments |
Hexachlorophene was removed from the over-the-counter market in the 1970s after neurotoxic effects were reported. Studies showed that between 0.3% and 6% of photo patch tested patients were allergic to this substance. [Marks, p. 232-3] Asthma reported in hospital employee; [Malo] In high-dose animal studies, hexachlorophene causes testicular damage and birth defects. [Frazier, p. 271-2] Acute exposure may cause CNS effects; A skin sensitizer; May cause asthma; [ICSC] |
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| Exposure Assessment |
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| Skin Designation (ACGIH) |
Not evaluated |
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| Vapor Pressure |
1.03 x 10 -10 mm Hg |
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| Lethal Concentration |
LC50 (rats) = 340 mg/m3 |
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| Reference Link |
International Chemical Safety Cards (WHO/IPCS/ILO) |
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| Adverse Effects |
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| Asthma |
Yes |
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| Skin Sensitizer |
Yes |
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| Neurotoxin |
Other CNS Neurotoxin |
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| Reproductive Toxin |
Yes |
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| IARC Carcinogen |
Not Classifiable |
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| Links to Other NLM Databases |
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| Health Studies |
Human Health Effects from Hazardous Substances Data Bank: HEXACHLOROPHENE
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