| Agent Name |
Hexachloronaphthalene |
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| CAS Number |
1335-87-1 |
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| Formula |
C10-H2-Cl6 |
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| Major Category |
Other Classes |
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| Synonyms |
Halowax 1014; [NIOSH] |
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| Category |
Halowaxes |
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| Description |
White to light-yellow solid with an aromatic odor; [NIOSH] |
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| Sources/Uses |
Used as additives to lubricants and cable insulation (fire retardants); [ACGIH] |
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| Comments |
Chlorinated naphthalenes may be absorbed through the skin. They cause fatal liver injury in animals in subchronic inhalation studies. Penta- and hexachloronaphthalene may cause in exposed workers acne-like lesions that itch severely. Tri-, tetra-, and octachloronaphthalene are non-acnegenic under the conditions of industrial use. Nine occupational fatalities from chlorinated naphthalene poisoning have been reported. Most cases of intoxication among cable workers, assemblers, and laborers involve either penta- or hexachloronaphthalene. A nonfatal case of toxic hepatitis was reported in an 18 year old female who was soldering electrical condensers. [ACGIH] Acne-form dermatitis is listed as an adverse effect for all of the halowaxes except trichloronaphthalene in the NIOSH Pocket Guide. |
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| Exposure Assessment |
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| Skin Designation (ACGIH) |
Yes |
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| Bioaccumulates |
Yes |
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| TLV (ACGIH) |
0.2 mg/m3 |
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| PEL (OSHA) |
0.2 mg/m3 |
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| IDLH (NIOSH) |
2 mg/m3 |
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| Excerpts from Documentation for IDLHs |
Animal data: Repeated exposure of rats to 8.9 mg/m3 of a mixture of hexachloronaphthalene and pentachloronaphthalene for up to 4.5 months produced jaundice and was fatal; minor liver injury still occurred at 1.16 mg/m3 [Drinker et al. 1937]. Hexachloronaphthalene has been shown to be more toxic than pentachloronaphthalene in ingestion studies with calves [Bell 1958]. Total doses of hexachloronaphthalene ranging from 5 to 23 mg/kg were given orally in mineral oil over 10 days and lacrimation, salivation, nasal discharge, depression, and anorexia occurred by the 5th day [Bell 1958].
Human data: It has been reported that fatal cases of hepatic injury have occurred from chronic exposures in a plant where air concentrations of mixed pentachloronaphthalenes and hexachloronaphthalenes ranged from 1 to 2 mg/m3 [Elkins 1959] |
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| Vapor Pressure |
3.3 x 10 -06 mm Hg |
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| Adverse Effects |
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| Dermatotoxin |
Chloracne |
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| Hepatotoxin |
Hepatotoxin, Primary |
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| Links to Other NLM Databases |
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| Health Studies |
Human Health Effects from Hazardous Substances Data Bank: HEXACHLORONAPHTHALENE
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