Z-360| A selective, orally available, 1,5-benzodiazepine-derivative gastrin/cholecystokinin 2 (CCK-2) receptor antagonist with potential antineoplastic activity. Z-360 binds to the gastrin/CCK-2 receptor, thereby preventing receptor activation by gastrin, a peptide hormone frequently associated with the proliferation of gastrointestinal and pancreatic tumor cells.
Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus) |
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Zactima| (Other name for: vandetanib) |
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zalcitabine| A synthetic dideoxynucleoside. After intracellular phosphorylation to its active metabolite, zalcitabine preferentially inhibits the gamma form of DNA polymerase present in tumor cell mitochondria, resulting in the inhibition of tumor cell mitochondrial DNA replication and tumor cell death. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus) |
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Zanosar| (Other name for: streptozocin) |
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Zarnestra| (Other name for: tipifarnib) |
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ZD6126| A water-soluble phosphate prodrug of N-acetylcolchinol with potential antiangiogenesis and antineoplastic activities. ZD6126 is converted in vivo into N-acetylcolchinol. N-acetylcolchinol binds to and destabilizes the tubulin cytoskeleton of endothelial cells in tumor blood vessels, which may result in tumor endothelial cel apoptosis, the selective occlusion of tumor blood vessels, cessation of tumor blood flow, and tumor necrosis. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus) |
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Zemplar| (Other name for: paricalcitol) |
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Zenapax| (Other name for: daclizumab) |
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Zerit| (Other name for: stavudine) |
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Zevalin| (Other name for: yttrium Y 90 ibritumomab tiuxetan) |
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Zevalin| (Other name for: ibritumomab tiuxetan) |
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zibotentan| An orally available selective antagonist of the endothelin-A (ET-A) receptor with potential antineoplastic activity. Zibotentan binds selectively to the ET-A receptor, thereby inhibiting endothelin-mediated mechanisms that promote tumor cell proliferation. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus) |
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ziconotide| A synthetic, nonopiod, twenty-five amino acid polybasic peptide analogue of an omega-conotoxin derived from the marine snail Conus magus with analgesic activity. Ziconotide appears to block neuronal N-type voltage-sensitive calcium channels (NCCB), inhibiting transmission from pain-sensing primary nociceptors. This agent may exhibit significant analgesic activity in refractory pain. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus) |
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zidovudine| A synthetic dideoxynucleoside. After intracellular phosphorylation to its active metabolite, zidovudine inhibits DNA polymerase, resulting in the inhibition of DNA replication and cell death. This agent also decreases levels of available pyrimidines. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus) |
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zileuton| A synthetic derivative of hydroxyurea with antiasthmatic properties. The leukotriene inhibitor zileuton blocks 5-lipoxygenase, which catalyzes the formation of leukotrienes from arachidonic acid; causes bronchodilation; decreases bronchial mucous secretion and edema; and may prevent or decrease the symptoms of asthma. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus) |
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zinc sulfate| A salt of the essential trace metal zinc. Zinc is involved in tissue repair and is an important constituent of some proteins, including those involved in taste and smell. Zinc sulfate supplementation may prevent radiation-induced aguesia. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus) |
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Zinecard| (Other name for: dexrazoxane hydrochloride) |
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zinostatin| An enediyne antineoplastic antibiotic hybrid containing an aminoglycoside chromophore. Zinostatin is isolated from the bacterium Streptomyces carzinostaticus. The aminoglycoside component of zinostatin intercalates into DNA and the benzene diradical intermediate of the enediyne core binds to the minor groove of DNA, resulting in single- and double-strand breaks in DNA and apoptosis. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus) |
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Zipan| (Other name for: promethazine hydrochloride) |
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Zocor| (Other name for: simvastatin) |
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Zofran| (Other name for: ondansetron) |
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Zofran| (Other name for: ondansetron hydrochloride) |
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Zoladex| (Other name for: goserelin) |
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zoledronic acid| A synthetic imidazole bisphosphonate analog of pyrophosphate with anti-bone-resorption activity. A third-generation bisphosphonate, zoledronic acid binds to hydroxyapatite crystals in the bone matrix, slowing their dissolution and inhibiting the formation and aggregation of these crystals. This agent also inhibits farnesyl pyrophosphate synthase, an enzyme involved in terpenoid biosynthesis. Inhibition of this enzyme prevents the biosynthesis of isoprenoid lipids, donor substrates of farnesylation and geranylgeranylation during the post-translational modification of small GTPase signalling proteins, which are important in the process of osteoclast turnover. Decreased bone turnover and stabilization of the bone matrix contribute to the analgesic effect of zoledronic acid with respect to painful osteoblastic lesions. The agent also reduces serum calcium concentrations associated with hypercalcemia. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus) |
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Zolinza| (Other name for: vorinostat) |
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Zoloft| (Other name for: sertraline hydrochloride) |
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zolpidem tartrate| The tartrate salt of an imidazopyridine with non-benzodiazepine benzodiazepine-receptor agonist and sedative-hypnotic activities. Zolpidem binds selectively to the alpha 1 subunit of the omega-1 (BZ1) receptor of the gamma-aminobutyric acid type A (GABA-A ) receptor-chloride ionophore complex, thereby opening neuronal chloride channels, hyperpolarizing neuronal cell membranes, and inhibiting neuronal firing. In contrast, benzodiazepines non-selectively bind to and activate all omega receptor subtypes, exhibiting anticonvulsant and myorelaxant activities in addition to a sedative-hypnotic activity. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus) |
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Zometa| (Other name for: zoledronic acid) |
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zorubicin| A benzoyl-hydrazone derivative of the anthracycline antineoplastic antibiotic daunorubicin. Zorubicin intercalates into DNA and interacts with topoisomerase II, thereby inhibiting DNA replication and repair and RNA and protein synthesis. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus) |
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zosuquidar trihydrochloride| A difluorocyclopropyl quinoline. Zosuquidar trihydrochloride binds with high affinity to P-glycoprotein and inhibits P-glycoprotein-mediated multidrug resistance (MDR). P-glycoprotein, encoded by the MDR-1 gene, is a member of the ATP-binding cassette superfamily of transmembrane transporters and prevents the intracellular accumulation of many natural product-derived cytotoxic agents. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus) |
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Zovirax| (Other name for: acyclovir) |
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Zovirax| (Other name for: acyclovir sodium) |
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Zyban| (Other name for: bupropion hydrochloride) |
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Zyflo| (Other name for: zileuton) |
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Zyloprim| (Other name for: allopurinol) |
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Zyprexa| (Other name for: olanzapine) |
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