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ketoconazole A synthetic derivative of phenylpiperazine with broad antifungal properties and potential antineoplastic activity. Ketoconazole inhibits sterol 14-a-dimethylase, a microsomal cytochrome P450-dependent enzyme, thereby disrupting synthesis of ergosterol, an important component of the fungal cell wall. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
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US brand names: | ![](https://webarchive.library.unt.edu/eot2008/20090114234139im_/http://www.cancer.gov/images/spacer.gif) | Nizoral Xolegel | | ![](https://webarchive.library.unt.edu/eot2008/20090114234139im_/http://www.cancer.gov/images/spacer.gif) | Foreign brand names: | ![](https://webarchive.library.unt.edu/eot2008/20090114234139im_/http://www.cancer.gov/images/spacer.gif) | Fungarest Fungoral Ketoderm Ketoisdin Orifungal M Panfungol | | ![](https://webarchive.library.unt.edu/eot2008/20090114234139im_/http://www.cancer.gov/images/spacer.gif) | Abbreviation: | ![](https://webarchive.library.unt.edu/eot2008/20090114234139im_/http://www.cancer.gov/images/spacer.gif) | KCZ | | ![](https://webarchive.library.unt.edu/eot2008/20090114234139im_/http://www.cancer.gov/images/spacer.gif) | Code name: | ![](https://webarchive.library.unt.edu/eot2008/20090114234139im_/http://www.cancer.gov/images/spacer.gif) | R-41400 | | ![](https://webarchive.library.unt.edu/eot2008/20090114234139im_/http://www.cancer.gov/images/spacer.gif) | Chemical structure name: | ![](https://webarchive.library.unt.edu/eot2008/20090114234139im_/http://www.cancer.gov/images/spacer.gif) | cis-1-acetyl-4-[4-[[2-(2,4-dichlorophenyl)-2-(1H-imidazole-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]piperazine | | ![](https://webarchive.library.unt.edu/eot2008/20090114234139im_/http://www.cancer.gov/images/spacer.gif) |
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