| Agent Name |
1,2-Diphenylhydrazine |
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| CAS Number |
122-66-7 |
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| Formula |
C12-H12-N2 |
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| Major Category |
Nitrogen Compounds |
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| Synonyms |
(sym)-Diphenylhydrazine; 1,1'-Hydrazodibenzene; Benzene, 1,1'-hydrazobis-; Benzene, hydrazodi-; Hydrazobenzen [Czech]; Hydrazobenzene; N,N'-Bianiline; N,N'-Diphenylhydrazine; Symmetrical diphenyl hydrazine; 1,2-Diphenylhydrazine (9CI); Hydrazine, 1,2-diphenyl-; [ChemIDplus] |
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| Category |
Hydrazines |
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| Description |
Orange powder or a bright orange crystalline solid; [CAMEO] |
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| Sources/Uses |
Used in the past in the United States to produce benzidine; the last manufacturer of benzidine-based dyes in the U.S. ceased production in 1988; Used as an intermediate in the pharmaceutical industry to produce phenylbutazone and sulfinpyrazone; [ATSDR ToxProfiles] |
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| Comments |
"1,2-Diphenylhydrazine oxidizes rapidly in the environment under aerobic conditions, with a half-life in water as short as 15 minutes. . . . it is possible that 1,2-diphenylhydrazine may cause methemoglobin in humans. However this would occur only if sufficient aniline were formed rapidly enough to exceed the capacity of methemoglobin reductase to reduce methemoglobin." Hepatic effects have been observed in high-dose animal experiments. [ATSDR ToxProfiles] |
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| Exposure Assessment |
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| Skin Designation (ACGIH) |
Not evaluated |
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| Vapor Pressure |
0.00044 mm Hg |
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| Reference Link |
ATSDR ToxFAQs - 1,2-Diphenylhydrazine |
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| Adverse Effects |
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| Methemoglobinemia |
Methemoglobinemia, Secondary |
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| Hepatotoxin |
Hepatotoxin, Secondary |
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| Links to Other NLM Databases |
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| Health Studies |
Human Health Effects from Hazardous Substances Data Bank: 1,2-DIPHENYLHYDRAZINE
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