| Agent Name |
Dimethylaminopropionitrile |
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| CAS Number |
1738-25-6 |
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| Formula |
C5-H10-N2 |
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| Major Category |
Nitrogen Compounds |
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| Synonyms |
3-(Dimethylamino)propanenitrile; 3-(Dimethylamino)propionitrile; 3-(N,N-Dimethylamino)propionitrile; 3-Dimethylaminopropannitril [Czech]; Dmapn; N,N-(Dimethylamino)-3-propionitrile; Propanenitrile, 3-(dimethylamino)-; Propionitrile, 3-(dimethylamino)-; beta-(N-Dimethylamino)propionitrile; beta-Dimethylaminopropionitrile; [ChemIDplus] |
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| Category |
Nitriles |
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| Description |
Colorless liquid; [NIOSH] |
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| Sources/Uses |
Dimethylaminopropionitrile was a component of catalysts used in manufacture of flexible polyurethane foams. [LaDou, p. 455-6] |
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| Comments |
Workers at polyurethane production plants developed neurogenic bladder dysfunction after exposure to the catalyst. [LaDou, p. 455-6] "A skin and eye irritant."; [HSDB] Symptoms of workers included erectile dysfunction and urinary retention. Cystometrograms confirmed neurogenic bladder. In follow-up studies 2 years later, 11 workers were still symptomatic with bladder and sexual dysfunction. A smaller group still had evidence of sensory neuropathy. [Rom, p. 644] See "NIAX catalyst ESN." |
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| Restricted |
Production of catalysts containing this chemical was discontinued after 1978; [Ladou, p. 455] |
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| Exposure Assessment |
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| Skin Designation (ACGIH) |
Not evaluated |
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| Explanatory Notes |
VP = 10 mmHg @ 135 degrees F; Flash point = 147 deg F; |
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| Flammability (NFPA) |
2: high ambient temperature required |
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| Adverse Effects |
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| Neurotoxin |
Sensorimotor Neuropathy |
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| Links to Other NLM Databases |
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| Health Studies |
Human Health Effects from Hazardous Substances Data Bank: 3-(DIMETHYLAMINO)-PROPANENITRILE
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