| Agent Name |
Dimethylaniline |
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| Alternative Name |
N,N-Dimethylaniline |
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| CAS Number |
121-69-7 |
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| Formula |
C8-H11-N |
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| Major Category |
Nitrogen Compounds |
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| Synonyms |
(Dimethylamino)benzene; Aniline, N,N-dimethyl-; Benzenamine, N,N-dimethyl-; Dimethylaniline; Dimethylphenylamine; Dwumetyloanilina [Polish]; N,N-(Dimethylamino)benzene; N,N-Dimethylaniline; N,N-Dimethylbenzenamine; N,N-Dimethylbenzeneamine; N,N-Dimethylphenylamine; NL 63-10P; Versneller NL 63/10; [ChemIDplus] UN2253 |
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| Category |
Amines, Aromatic |
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| Description |
Pale yellow, oily liquid with an amine-like odor; Note: A solid below 36 degrees F; [NIOSH] |
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| Sources/Uses |
Used in the synthesis of vanillin, methyl violet, and Michler's ketone; also used as a hardener for plastic resins and a acid scavenger in the manufacture of semisynthetic penicillins and cephalosporins; [ACGIH] |
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| Comments |
N,N-diethylaniline and N,N-dimethylaniline are potent methemoglobin-inducers with toxicity similar to aniline. [ILO Encyclo, Guide to Chemicals: Aromatic Amino Compounds, Vol 4, 104.1-104.416] Listed in a table of "Industrial Chemicals for Which Methemoglobin Formation is the Principal Cause of Toxicity"; [ACGIH] A skin and eye irritant that can induce methemoglobinemia; Inhalation of high concentrations can cause CNS depression; [ICSC] |
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| Exposure Assessment |
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| BEI |
Methemoglobin in blood = 1.5% of hemoglobin during or at end of shift. [ACGIH] |
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| Skin Designation (ACGIH) |
Yes |
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| TLV (ACGIH) |
5 ppm |
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| STEL (ACGIH) |
10 ppm |
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| PEL (OSHA) |
5 ppm |
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| MAK |
5 ppm |
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| IDLH (NIOSH) |
100 ppm |
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| Excerpts from Documentation for IDLHs |
N,N�Dimethylaniline has been reported to be quantitatively less toxic than aniline but produces a very similar effect -- notably, methemoglobinemia [Clayton and Clayton 1981]. |
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| Vapor Pressure |
0.7 mm Hg |
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| Odor Threshold Low |
0.001 ppm |
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| Odor Threshold High |
0.2 ppm |
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| Lethal Concentration |
LCLo (rats) = 250 mg/m3/4H |
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| Explanatory Notes |
Odor threshold from AIHA; Flash point = 63 deg C; |
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| Flammability (NFPA) |
2: high ambient temperature required |
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| Adverse Effects |
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| Methemoglobinemia |
Methemoglobinemia, Primary |
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| IARC Carcinogen |
Not Classifiable |
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| Links to Other NLM Databases |
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| Health Studies |
Human Health Effects from Hazardous Substances Data Bank: N,N-DIMETHYLANILINE
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