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oblimersen
A phosphorothioate antisense oligonucleotide. Targeted to the initiation codon region of the bcl-2 mRNA, oblimersen inhibits bcl-2 mRNA translation, resulting in decreased expression of the bcl-2 protein, an apoptotic inhibitor expressed in some types of cancer and linked to tumor drug resistance. This agent may enhance the efficacy of standard cytotoxic chemotherapy. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
| Synonyms: | | augmerosen
bcl-2 antisense oligodeoxynucleotide (G3139)
bcl-2 antisense oligonucleotide (G3139)
BCL-2 antisense/G3139
bcl-2 AO G3139
BCL2 gene anticode oligodeoxynucleotide
G3139 antisense oligonucleotide
oblimersen sodium | | | | US brand name: | | Genasense | | | | Code name: | | G3139 | | |
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