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Agent Name Methyl silicate
Alternative Name Tetramethoxysilane
CAS Number 681-84-5
Formula C4-H12-O4-Si
Major Category Metals
Synonyms MSP 150; Methyl Silicate 39; Methyl orthosilicate; Methyl silicate; Methyl silicate ((CH3)4SiO4); Methyl silicate ((MeO)4Si); Methyl silicate 28; SIT 7510.0; Silane, tetramethoxy-; Silicic acid, methyl ester of ortho-; Silicic acid, tetramethyl ester; TL 190; TMOS; TSL 8114; Tetra-methyl orthosilicate; Tetramethoxysilane; Tetramethyl silicate; Tetramethylsilikat [Czech]; [ChemIDplus] UN2606
Category Metalloids and Compounds
Description Clear, colorless liquid. [Note: A solid below 28 degrees F.]; [NIOSH]
Sources/Uses Used in corrosion resistant coatings and in catalysts; used to manufacture silicone; [ACGIH]
Comments Severe damage to the cornea has been reported after occupational exposure. Experimental animals exposed repeatedly to 30 ppm develop respiratory disease with bronchiolar inflammation. [ACGIH] Its severe corneal toxicity is delayed by several hours, and workers have little or no immediate eye symptoms. [HSDB] Has potential to cause pulmonary edema after high inhalation exposure; May have effects on liver and kidneys; [ICSC]
Exposure Assessment
Skin Designation (ACGIH) No
TLV (ACGIH) 1 ppm
Vapor Pressure 12 mm Hg
Lethal Concentration LCLo (rats) = 250 ppm/4h
Explanatory Notes Flash point = 205 deg F;
Reference Link International Chemical Safety Cards (WHO/IPCS/ILO)
Flammability (NFPA) 3: may ignite at ambient temperature
Adverse Effects
Toxic Pneumonitis Yes
Hepatotoxin Hepatotoxin, Secondary
Links to Other NLM Databases
Health Studies Human Health Effects from Hazardous Substances Data Bank: TETRAMETHYL SILICATE  
Toxicity Information Search TOXNET
Chemical Information Search ChemIDplus
Related Information in Haz-Map
Diseases Occupational diseases associated with exposure to this agent:





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Last updated: January, 2009