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aflibercept
A protein comprised of segments of the extracellular domains of human
vascular endothelial growth factor receptors 1 (VEGFR1) and 2 (VEGFR2)
fused to the constant region (Fc) of human IgG1 with potential
antiangiogenic activity. Afilbercept, functioning as a soluble decoy
receptor, binds to pro-angiogenic vascular endothelial growth factors
(VEGFs), thereby preventing VEGFs from binding to their cell receptors.
Disruption of the binding of VEGFs to their cell receptors may result in
the inhibition of tumor angiogenesis, metastasis, and ultimately tumor
regression. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
| Synonyms: | | vascular endothelial growth factor trap
VEGF Trap
VEGF Trap R1R2 | | |
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