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sargramostim A recombinant therapeutic agent which is chemically identical to or similar to endogenous human GM-CSF. Binding to specific cell surface receptors, sargramostim modulates the proliferation and differentiation of a variety of hematopoietic progenitor cells with some specificity towards stimulation of leukocyte production and may reverse treatment-induced neutropenias. This agent also promotes antigen presentation, up-regulates antibody-dependent cellular cytotoxicity (ADCC), and increases interleukin-2-mediated lymphokine-activated killer cell function; it may also augment host antitumoral immunity. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
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Synonyms: | ![](https://webarchive.library.unt.edu/eot2008/20090115001139im_/http://www.cancer.gov/images/spacer.gif) | 23-L-leucine colony-stimulating factor 2 granulocyte macrophage colony-stimulating factor | | ![](https://webarchive.library.unt.edu/eot2008/20090115001139im_/http://www.cancer.gov/images/spacer.gif) | US brand names: | ![](https://webarchive.library.unt.edu/eot2008/20090115001139im_/http://www.cancer.gov/images/spacer.gif) | Leukine Prokine | | ![](https://webarchive.library.unt.edu/eot2008/20090115001139im_/http://www.cancer.gov/images/spacer.gif) | Abbreviations: | ![](https://webarchive.library.unt.edu/eot2008/20090115001139im_/http://www.cancer.gov/images/spacer.gif) | GM-CSF rhu GM-CFS | | ![](https://webarchive.library.unt.edu/eot2008/20090115001139im_/http://www.cancer.gov/images/spacer.gif) |
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