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levothyroxine sodium The sodium salt of levothyroxine, a synthetic levoisomer of thyroxine (T4) that is similar to the endogenous hormone produced by the thyroid gland. In peripheral tissues, levothyroxine is deiodinated by 5'-deiodinase to form triiodothyronine (T3). T3 enters the cell and binds to nuclear thyroid hormone receptors; the activated hormone-receptor complex in turn triggers gene expression and produces proteins required in the regulation of cellular respiration; thermogenesis; cellular growth and differentiation; and the metabolism of proteins, carbohydrates and lipids. T3 also exhibits cardiostimulatory effects. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
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Synonym: | ![](https://webarchive.library.unt.edu/eot2008/20090115021203im_/http://www.cancer.gov/images/spacer.gif) | Therapeutic Levothyroxine | | ![](https://webarchive.library.unt.edu/eot2008/20090115021203im_/http://www.cancer.gov/images/spacer.gif) | US brand names: | ![](https://webarchive.library.unt.edu/eot2008/20090115021203im_/http://www.cancer.gov/images/spacer.gif) | Levoxyl Synthroid | | ![](https://webarchive.library.unt.edu/eot2008/20090115021203im_/http://www.cancer.gov/images/spacer.gif) |
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