| Agent Name |
Propylene glycol dinitrate |
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| CAS Number |
6423-43-4 |
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| Formula |
C3-H6-N2-O6 |
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| Major Category |
Nitrogen Compounds |
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| Synonyms |
PGDN; Propylene glycol-1,2-dinitrate; 1,2-Propylene glycol dinitrate; 1,2-Propanediol dinitrate; Isopropylene nitrate; Propylene dinitrate; Propylene glycol dinitrate; Propylene nitrate; [ChemIDplus] |
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| Category |
Nitrates and Nitrites |
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| Description |
Colorless liquid with a disagreeable odor. [Note: A solid below 18 degrees F.]; [NIOSH] |
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| Sources/Uses |
Used in Otto Fuel II, a torpedo propellant. [ACGIH] |
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| Comments |
Listed in the ACGIH table: "Examples of Industrial Chemicals for Which Methemoglobin Formation is NOT the Principal Cause of Toxicity"; Headache is a common symptom in new employees, but tolerance develops after repeated exposures. Volunteers exposed at 0.5 ppm for 6 to 8 hours showed impaired performance similar to the effects in these same subjects at blood alcohol concentrations of 100 to 150 mg/10 ml. Male volunteers exposed to levels from 0.03-1.5 ppm over a range of time showed no significant hematological effects. No evidence of chronic neurological effects was found in a group of 87 workers at a torpedo manufacturing plant where PGDN peak air concentrations measured from not detectable to 0.22 ppm (90% below 0.1 ppm). [ACGIH] An eye irritant; Can induce methemoglobinemia; [ICSC] |
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| Exposure Assessment |
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| BEI |
Methemoglobin in blood = 1.5% of hemoglobin during or at end of shift. [ACGIH] |
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| Skin Designation (ACGIH) |
Yes |
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| TLV (ACGIH) |
0.05 ppm |
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| MAK |
0.05 ppm |
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| Vapor Pressure |
0.07 mm Hg |
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| Lethal Concentration |
LC50 (rats) > 1,350 mg/m3/4h |
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| Adverse Effects |
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| Methemoglobinemia |
Methemoglobinemia, Secondary |
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| Links to Other NLM Databases |
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| Health Studies |
Human Health Effects from Hazardous Substances Data Bank: 1,2-PROPANEDIOL DINITRATE
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