| Agent Name |
Podofilox |
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| CAS Number |
518-28-5 |
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| Formula |
C22-H22-O8 |
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| Major Category |
Other Uses |
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| Synonyms |
(5R,5aR,8aR,9R)-5,8,8a,9-Tetrahydro-9-hydroxy-5-(3,4,5-trimethoxyphenyl)furo(3',4':6,7)naphtho(2,3-d)-1,3-dioxol-6(5aH)-one; Condylox; Furo(3',4':6,7)naphtho(2,3-d)-1,3-dioxol-6(5aH)-one,; 5,8,8a,9-tetrahydro-9-hydroxy-5-(3,4,5-trimethoxyphenyl)-,; (5R-(5alpha,5abeta,8aalpha,9alpha))-; Podofilox; Podophyllinic acid lactone; Podophyllotoxin; Podophyllotoxin 7; [ChemIDplus] |
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| Category |
Pharmaceuticals |
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| Description |
Light-brown to greenish-yellow powder; Commercial resin preparations contain 5-25% podophyllum. [INCHEM] |
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| Sources/Uses |
Used in the treatment of warts and corns; [INCHEM] "Podophyllotoxin, otherwise known as podofilox is a non-alkaloid toxin in the lignin family present at concentrations of 0.3 to 1.0% by mass in the rhizome of American Mayapple Podophyllum peltatum. . . . Podophyllotoxin is the pharmacological base for the important anti-cancer drug Etoposide." [Wikipedia] |
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| Comments |
"The main active constituent of the resin from the roots of may apple or mandrake (Podophyllum peltatum and P. emodi). It is a potent spindle poison, toxic if taken internally, and has been used as a cathartic. It is very irritating to skin and mucous membranes, has keratolytic actions, has been used to treat warts and keratoses, and may have antineoplastic properties, as do some of its congeners and derivatives." [ChemIDplus] |
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| Reference Link |
INCHEM: Podophyllum |
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| Exposure Assessment |
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| Vapor Pressure |
8.34 x 10 -15 mm Hg |
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| Explanatory Notes |
Melting point = 114-118 deg C; [INCHEM] |
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| Links to Other NLM Databases |
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| Health Studies |
Human Health Effects from Hazardous Substances Data Bank: PODOFILOX
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