Haz-Map: Occupational Exposure to Hazardous Agents

Exposure Assessment
Agent Name	Polymethylene polyphenyl isocyanate
CAS Number	9016-87-9
Major Category	Plastics & Rubber
Synonyms	PAPI; Polymeric diphenylmethane diisocyanate; Isocyanic acid, polymethylenepolyphenylene ester; Polymeric MDI; Polymeric Methylene Diphenyl Diisocyanate; [ChemFinder]
Category	Diisocyanates
Description	Dark amber viscous liquid; [HSDB]
Sources/Uses	This resin is used as a binder in particle board and foundry cores. It is used to make polyurethane elastomers for shoes and automobile bumpers. [HSDB]
Comments	Occupational asthma reported in paint shop worker; [Malo] See "DIISOCYANATES."
Reference Link	Prevalence of occupational asthma in spray painters exposed to several types of isocyanates, including polymethylene polyphenylisocyanate
Skin Designation (ACGIH)	Not evaluated
MAK	0.05 ppm, inhalable fraction
Vapor Pressure	3 x 10 ^-06 mm Hg
Lethal Concentration	LC50 (rats) = 490 mg/m3/4h
Adverse Effects
Asthma	Yes
IARC Carcinogen	Not Classifiable
Links to Other NLM Databases
Health Studies	Human Health Effects from Hazardous Substances Data Bank: POLYMETHYLENE POLYPHENYL ISOCYANATE
Toxicity Information	Search TOXNET
Chemical Information	Search ChemIDplus
Biomedical References	Search PubMed
Related Information in Haz-Map
Diseases	Occupational diseases associated with exposure to this agent: Asthma, occupational
Processes	Industrial Processes with risk of exposure: Molding and Core Making Painting (Pigments, Binders, and Biocides) Plastic Composites Manufacturing