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Agent Name Ethyl silicate
Alternative Name Tetraethylorthosilicate
CAS Number 78-10-4
Formula C8-H20-O4-Si
Major Category Metals
Synonyms Dynasil A; ES 100; ES 28; ES 28 (ester); Ethyl orthosilicate; Ethyl silicate, ((EtO)4Si); Etylu krzemian [Polish]; Orthosilicic acid, tetraethyl ester; Silane, tetraethoxy-; Silicate d'ethyle [French]; Silicate tetraethylique [French]; Silicic acid, tetraethyl ester; Silicon ethoxide; Silicon tetraethoxide; Silikan L; TEOS; TEOS (VAN); Tetraethoxysilane; Tetraethoxysilicon; Tetraethyl orthosilicate; Tetraethyl silicate; Tetraethyl-O-silicate; Tetraethylsilikat [Czech]; [ChemIDplus] UN1292
Category Metalloids and Compounds
Description Colorless liquid with a sharp, alcohol-like odor; [NIOSH]
Sources/Uses Used in mortar and surface coatings to improve resistance to weather and chemical corrosion; [ACGIH] Used in the semiconductor/electronics industry; [CSH, p. 375] Used in castings for alloys with high melting points, copper alloys, and dental prosthetic devices; Also used as a source of silicon dioxide by vapor deposition and to produce refractory bricks and heat-resistant paints; [HSDB]
Comments Rats that survived concentrations of 400 ppm for 7 hours/day for 30 days show liver, kidney, and lung damage. [ACGIH] A skin and respiratory tract irritant; Liquid defats the skin and vapor may depress consciousness; [ICSC] In high-dose animal experiments, it acts as a general anesthetic; [ChemIDplus]
Exposure Assessment
Skin Designation (ACGIH) No
TLV (ACGIH) 10 ppm
PEL (OSHA) 100 ppm
MAK 10 ppm
IDLH (NIOSH) 700 ppm
Excerpts from Documentation for IDLHs Human data: Exposure to a concentration of 1,200 ppm caused lacrimation and 250 ppm caused irritation of the eyes and nose [Smyth and Seaton 1940]. It has been stated that 700 ppm is probably intolerable for more than 30 minutes [Smyth and Seaton 1940].
Vapor Pressure 1.88 mm Hg
Odor Threshold Low 3.6 ppm
Lethal Concentration LCLo (rats) = 1,000 ppm/4H
Explanatory Notes Detection odor threshold from AIHA (mean = 3.6 ppm); Flash point = 99 deg F;
Flammability (NFPA) 3: may ignite at ambient temperature
Adverse Effects
Neurotoxin CNS Solvent Syndrome
Hepatotoxin Hepatotoxin, Secondary
Nephrotoxin Yes
Links to Other NLM Databases
Health Studies Human Health Effects from Hazardous Substances Data Bank: ETHYL SILICATE  
Toxicity Information Search TOXNET
Chemical Information Search ChemIDplus
Related Information in Haz-Map
Diseases Occupational diseases associated with exposure to this agent:
Processes Industrial Processes with risk of exposure:





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Last updated: January, 2009