| Agent Name |
Ethyl amyl ketone |
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| Alternative Name |
5-Methyl-3-heptanone |
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| CAS Number |
541-85-5 |
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| Formula |
C8-H16-O |
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| Major Category |
Solvents |
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| Synonyms |
2-Methylbutyl ethyl ketone; 3-Methyl-5-heptanone; 5-Methyl-3-heptanone; Ethyl 2-methylbutyl ketone; Ethyl sec-amyl ketone; 3-Heptanone, 5-methyl-
[ChemIDplus] EAK; [ACGIH]
|
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| Category |
Ketones |
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| Description |
Colorless liquid with a pungent odor; [NIOSH] |
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| Sources/Uses |
Used as a solvent for resins; [ACGIH] |
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| Comments |
Narcosis induced in animal inhalation studies. Animals fed 820 mg/kg/day develop evidence of peripheral neuropathy. [ACGIH] A skin, eye, and respiratory tract irritant; Inhalation of high concentrations can cause CNS depression; [ICSC] |
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| Exposure Assessment |
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| Skin Designation (ACGIH) |
No |
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| TLV (ACGIH) |
10 ppm |
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| PEL (OSHA) |
25 ppm |
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| MAK |
10 ppm |
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| IDLH (NIOSH) |
100 ppm |
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| Excerpts from Documentation for IDLHs |
Basis for original (SCP) IDLH: The chosen IDLH is based on the statement by Patty [1963] that 0 of 6 rats died, but 3 of 6 mice died when exposed for 4 hours to about 3,000 ppm [Shell 1958]. . . . Human data: Humans exposed to 25 ppm experienced irritation of the eyes and respiratory tract and detected a strong odor, while 100 ppm caused irritation of the mucous membranes, headache, and nausea which was too severe to tolerate for more than a few minutes [Clayton and Clayton 1981] |
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| Vapor Pressure |
5.03 mm Hg |
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| Odor Threshold Low |
5.9 ppm |
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| RD50 |
760 ppm |
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| Lethal Concentration |
LCLo (rats) =3,484 ppm/8H |
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| Explanatory Notes |
Odor threshold from AIHA; |
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| Adverse Effects |
|---|
| Neurotoxin |
CNS Solvent Syndrome |
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| Links to Other NLM Databases |
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