| Agent Name |
Endrin |
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| CAS Number |
72-20-8 |
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| Formula |
C12-H8-Cl6-O |
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| Major Category |
Pesticides |
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| Synonyms |
1,2,3,4,10,10-Hexachloro-6,7-epoxy-1,4,4a,5,6,7,8,8a-octahydro-1,4-endo,endo-5,8-dimethanonaphthalene; Hexadrin; [NIOSH] |
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| Category |
Organochlorine Pesticides |
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| Description |
Colorless to tan, crystalline solid with a mild, chemical odor. [insecticide]; [NIOSH] |
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| Sources/Uses |
Formerly used as an insecticide, as an avicide, and as a rodenticide; [HSDB] |
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| Comments |
High-dose animal studies show that organochlorine insecticides can cause liver injury. [LaDou, p. 553] "No evidence of hepatic injury in humans as the result of environmental contamination." [Zimmerman, p. 414] |
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| Restricted |
Voluntary cancellation in 1985; all U.S. registrations cancelled; [EPA Pesticides, p. 56] |
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| Exposure Assessment |
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| Skin Designation (ACGIH) |
Yes |
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| Bioaccumulates |
Yes |
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| TLV (ACGIH) |
0.1 mg/m3 |
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| PEL (OSHA) |
0.1 mg/m3 |
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| MAK |
0.1 mg/m3, inhalable fraction |
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| IDLH (NIOSH) |
2 mg/m3 |
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| Excerpts from Documentation for IDLHs |
Human data: An oral dose of 171 mg/kg has been reported to be lethal [Runhaar et al. 1985]. It has also been reported that the approximate oral dose producing convulsions is about 0.2 mg/kg [Hayes 1982]. [Note: Oral doses of 171 mg/kg or 0.2 mg/kg are equivalent to a 70�kg worker being exposed to about 8,000 mg/m3 or 9 mg/m3, respectively, for 30 minutes, assuming a breathing rate of 50 liters per minute and 100% absorption.] |
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| Vapor Pressure |
3 x 10 -06 mm Hg |
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| Half Life |
No reports found; [TDR, p. 613] |
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| Reference Link |
ATSDR - ToxFAQs - Endrin |
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| Adverse Effects |
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| Hepatotoxin |
Hepatotoxin, Secondary |
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| Other Poison |
Organochlorine Pesticide |
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| IARC Carcinogen |
Not Classifiable |
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| Links to Other NLM Databases |
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| Health Studies |
Human Health Effects from Hazardous Substances Data Bank: ENDRIN
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