| Agent Name |
Isopropylamine |
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| CAS Number |
75-31-0 |
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| Formula |
C3-H9-N |
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| Major Category |
Nitrogen Compounds |
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| Synonyms |
1-Methylethylamine; 2-Amino-propaan [Dutch]; 2-Amino-propano [Italian]; 2-Aminopropan [German]; 2-Aminopropane; 2-Propanamine; 2-Propaneamine; 2-Propylamine; Isopropilamina [Italian]; Monoisopropylamine; Propanal, 2-amino-; Propane, 2-amino-; sec-Propylamine; [ChemIDplus] UN1221 |
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| Category |
Amines, Aliphatic |
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| Description |
Colorless liquid with an ammonia-like odor; Note: A gas above 91 degrees F; [NIOSH] |
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| Sources/Uses |
Used as a solvent and as an intermediate in the synthesis of dyes, rubber additives, pesticides, surface active agents, and pharmaceuticals; [ACGIH] |
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| Comments |
Liquid causes first degree burns on short exposure. [CHRIS] Corrosive to skin; [Quick CPC] Acute animal toxicology studies indicate that inhaled isopropylamine has a potency about one half that of n-butylamine. It causes respiratory irritation, and can cause pulmonary edema. [ACGIH] Halo vision and other visual disturbances usually resolve within 24 hours. [CHEMINFO] |
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| Exposure Assessment |
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| Skin Designation (ACGIH) |
No |
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| TLV (ACGIH) |
5 ppm |
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| STEL (ACGIH) |
10 ppm |
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| PEL (OSHA) |
5 ppm |
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| MAK |
5 ppm |
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| IDLH (NIOSH) |
750 ppm |
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| Excerpts from Documentation for IDLHs |
Other animal data: It has been reported that rats have survived an exposure to 4,000 ppm for 4 hours [Smyth et al. 1951].
Human data: Volunteers have complained of nose and throat irritation after brief exposures to concentrations ranging from 10 to 20 ppm [Amoore and Hautala 1983]. |
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| Vapor Pressure |
580 mm Hg |
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| Odor Threshold Low |
0.21 ppm |
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| Odor Threshold High |
0.7 ppm |
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| Lethal Concentration |
LC50 (rats) = 4,000 ppm/4H |
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| Explanatory Notes |
Detection odor threshold from AIHA (mean = 0.21 ppm); Flash point = -26 deg C; |
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| Reference Link |
International Chemical Safety Cards (WHO/IPCS/ILO) |
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| Flammability (NFPA) |
4: burns readily |
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| Adverse Effects |
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| Toxic Pneumonitis |
Yes |
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| Dermatotoxin |
Skin Burns |
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| Links to Other NLM Databases |
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| Health Studies |
Human Health Effects from Hazardous Substances Data Bank: ISOPROPYLAMINE
|
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