| Agent Name |
1-Nitropropane |
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| CAS Number |
108-03-2 |
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| Formula |
C3-H7-N-O2 |
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| Major Category |
Nitrogen Compounds |
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| Synonyms |
1-NP; 1-Nitropropane; [ChemIDplus] UN2608 |
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| Category |
Nitros, Aliphatic |
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| Description |
Colorless liquid with a somewhat disagreeable odor; [NIOSH] |
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| Sources/Uses |
Used in organic chemical synthesis and as a rocket propellant, gasoline additive, and solvent; [ACGIH] Used as a solvent for waxes, resins, lacquers, synthetic rubber, fats, oils, dyes, inks, and other organic materials; [HSDB] |
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| Comments |
A hepatotoxin in animals after oral administration or inhalation; [ACGIH] An eye and respiratory tract irritant; [ICSC] Volunteers tolerated 100 ppm for 8 hours; 150 ppm caused irritation of the nose and throat; A weak inducer of methemoglobinemia; [CHEMINFO] Causes CNS depression and anesthesia in lethal concentration animal studies; [ChemIDplus] |
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| Exposure Assessment |
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| Skin Designation (ACGIH) |
No |
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| TLV (ACGIH) |
25 ppm |
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| PEL (OSHA) |
25 ppm |
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| MAK |
25 ppm |
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| IDLH (NIOSH) |
1000 ppm |
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| Excerpts from Documentation for IDLHs |
Other animal data: It has been reported that rabbits survived a 1�hour exposure to 10,000 ppm [Machle et al. 1940]. Human data: Volunteers found brief exposures to concentrations exceeding 100 ppm to cause eye irritation [Silverman et al. 1946]. |
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| Vapor Pressure |
10.1 mm Hg |
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| Odor Threshold Low |
7.7 ppm |
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| Odor Threshold High |
140 ppm |
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| Lethal Concentration |
LC50 (rats) = 3,100 ppm/8H |
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| Explanatory Notes |
Detection odor threshold from AIHA (mean = 140 ppm); Flash point = 36 deg C; |
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| Flammability (NFPA) |
3: may ignite at ambient temperature |
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| Adverse Effects |
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| Neurotoxin |
CNS Solvent Syndrome |
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| Hepatotoxin |
Hepatotoxin, Secondary |
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| Links to Other NLM Databases |
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| Health Studies |
Human Health Effects from Hazardous Substances Data Bank: 1-NITROPROPANE
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