| Agent Name |
Nitrogen trifluoride |
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| CAS Number |
7783-54-2 |
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| Formula |
F3-N |
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| Major Category |
Toxic Gases & Vapors |
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| Synonyms |
Nitrogen fluoride; Nitrogen fluoride (NF3); Perfluoroammonia; Trifluoroamine; Trifluoroammonia; [ChemIDplus] UN2451 |
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| Category |
Other Toxic Gases & Vapors |
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| Description |
Colorless gas with a moldy odor. [Note: Shipped as a nonliquefied compressed gas.]; [NIOSH] |
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| Sources/Uses |
Used in high-energy fuels and in chemical synthesis; [ACGIH] |
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| Comments |
Causes liver/kidney injury in rats exposed to 100 ppm 7 hours/day, 5 days a week for 19 weeks; No fluorosis of teeth or bones in these animals; Listed in the table "Examples of Industrial Chemicals for Which Methemoglobin Formation is NOT the Principal Cause of Toxicity"; [ACGIH] May cause fluorosis after high, prolonged, and repeated exposures; [ICSC] "Rats died from exposure to 10,000 ppm for 60 to 70 minutes; the methemoglobin concentrations at the time of death were equivalent to 60 to 70% of available hemoglobin. Animals exposed to nearly lethal concentrations suffered severe respiratory distress and cyanosis due to methemoglobinemia; severely affected animals showed incoordination, collapse and convulsions." [NIOSH Guidelines for Chemical Hazards] |
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| Exposure Assessment |
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| BEI |
Methemoglobin in blood = 1.5% of hemoglobin during or at end of shift. [ACGIH] |
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| Skin Designation (ACGIH) |
No |
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| TLV (ACGIH) |
10 ppm |
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| PEL (OSHA) |
10 ppm |
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| IDLH (NIOSH) |
1000 ppm |
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| Excerpts from Documentation for IDLHs |
Basis for original (SCP) IDLH: The chosen IDLH is based on the mouse 4�hour LC50 of 2,000 ppm cited by Deichmann and Gerarde [1969]. Deichmann and Gerarde [1969] also stated that nitrogen trifluoride is a pulmonary irritant comparable in toxicity to the oxides of nitrogen. . . . Human data: None relevant for use in determining the revised IDLH. |
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| Lethal Concentration |
LC50 (rats) = 6,700 ppm/1H |
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| Adverse Effects |
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| Methemoglobinemia |
Methemoglobinemia, Secondary |
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| Hepatotoxin |
Hepatotoxin, Secondary |
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| Nephrotoxin |
Yes |
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| Links to Other NLM Databases |
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| Health Studies |
Human Health Effects from Hazardous Substances Data Bank: NITROGEN TRIFLUORIDE
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