| Agent Name |
Nitrogen mustard (HN-3) |
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| Alternative Name |
Tris(2-chloroethyl)amine |
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| CAS Number |
555-77-1 |
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| Formula |
C6-H12-Cl3-N |
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| Major Category |
Toxic Gases & Vapors |
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| Synonyms |
2,2',2''-Trichlorotriethylamine; 2-Chloro-N,N-bis(2-chloroethyl)ethanamine; A 8729; Agent HN3; Ethanamine, 2-chloro-N,N-bis(2-chloroethyl)-; HN-3; HN3; Sinalost base; TL 145; TS 160; Tri-(2-chloroethyl)amine; Trichlormethinum [INN-Latin]; Triclormetina [INN-Spanish]; Triethylamine, 2,2',2"-trichloro-; Trimitan base; Trimustine; Tris(beta-chloroethyl)amine; UN 2810; [ChemIDplus] |
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| Category |
Chemical Weapons |
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| Description |
Colorless to pale yellow, oily liquid with a faint butter almond odor; [ATSDR-MMG] |
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| Sources/Uses |
Used in medicine as an antineoplastic drug; A vesicant that has not been used as a chemical weapon; [HSDB] |
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| Comments |
"Nitrogen mustards are vesicants causing skin, eye, and respiratory tract injury. Although these agents cause cellular changes within several minutes of contact, the onset of pain and other clinical effects is delayed for hours. Nitrogen mustards are alkylating agents that may cause bone marrow suppression and neurologic toxicity. . . . Nitrogen mustards may decrease fertility." [ATSDR MMG] |
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| Reference Link |
ATSDR Medical Management Guidelines: Nitrogen Mustard |
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| Exposure Assessment |
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| Skin Designation (ACGIH) |
Not evaluated |
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| Vapor Pressure |
0.01 mm Hg |
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| Explanatory Notes |
LCt50 = 1,500 mg-min/m�; [ATSDR-MMG] |
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| Adverse Effects |
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| Anemia |
Anemia, Aplastic |
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| Dermatotoxin |
Skin Burns |
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| Neurotoxin |
Other CNS Neurotoxin |
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| Reproductive Toxin |
Yes |
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| IARC Carcinogen |
Probable Carcinogen |
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| Links to Other NLM Databases |
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