| Agent Name |
Nitrogen mustard (HN-2) |
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| Alternative Name |
Mechlorethamine |
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| CAS Number |
51-75-2 |
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| Formula |
C5-H11-Cl2-N |
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| Major Category |
Toxic Gases & Vapors |
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| Synonyms |
Bis(beta-chloroethyl)methylamine; N,N-Bis(2-chloroethyl)methylamine; Bis(2-chloroethyl)methylamine; Caryolysine; Chloramine (the Nitrogen Mustard); Chlorethazine; Chlormethine; 2-Chloro-N-(2-chloroethyl)-N-methylethanamine; Dichlor Amine; Dichloren (German); Beta,beta'-Dichlorodiethyl-N-methylamine; Di(chloroethyl)methylamine; N,N-Di(chloroethyl)methylamine; Di(2-chloroethyl)methylamine; 2,2'-Dichloro-N-methyldiethylamine; Diethylamine, 2,2'-dichloro-N-methyl-; Embichin; Ethanamine, 2-Chloro-N-(2-chloroethyl)-N-methyl-; HN2; HN-2; N-Methyl-Lost (German); N-Methyl-bis-chloraethylamin (German); Methylbis(chloroethylamine); Methylbis(beta-chloroethyl)amine; N-Methylbis(beta-chloroethyl)amine; N-Methylbis(2-chloroethyl)amine; Methylbis(2-chloroethyl)amine; N-Methyl-2,2'-dichlorodiethylamine; Methyldi(2-chloroethyl)amine; Mustargen; Mustine; Nitrogen mustard; Stickstofflost (ebewe); TL 146; [HSDB] |
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| Category |
Chemical Weapons |
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| Description |
Colorless to pale yellow, oily liquid with a faint soapy odor or fruity odor at high concentrations; [ATSDR-MMG] |
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| Sources/Uses |
Used as an antineoplastic drug and formerly used as a gas warfare agent; [HSDB] |
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| Comments |
"Nitrogen mustards are vesicants causing skin, eye, and respiratory tract injury. Although these agents cause cellular changes within several minutes of contact, the onset of pain and other clinical effects is delayed for hours. Nitrogen mustards are alkylating agents that may cause bone marrow suppression and neurologic toxicity. . . . Nitrogen mustards may decrease fertility." [ATSDR MMG] |
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| Reference Link |
ATSDR Medical Management Guidelines: Nitrogen Mustard |
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| Exposure Assessment |
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| Skin Designation (ACGIH) |
Not evaluated |
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| TIH |
Yes |
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| Vapor Pressure |
0.42 mm Hg |
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| Explanatory Notes |
Danger of sensitization of skin; [MAK] LCt50 = 3,000 mg-min/m�; [ATSDR MMG] |
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| Adverse Effects |
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| Anemia |
Anemia, Aplastic |
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| Dermatotoxin |
Skin Burns |
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| Neurotoxin |
Other CNS Neurotoxin |
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| Reproductive Toxin |
Yes |
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| IARC Carcinogen |
Probable Carcinogen |
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| Links to Other NLM Databases |
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| Health Studies |
Human Health Effects from Hazardous Substances Data Bank: MECHLORETHAMINE
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