| Agent Name |
5-Nitro-2-toluidine |
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| Alternative Name |
Nitro-o-toluidine |
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| CAS Number |
99-55-8 |
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| Formula |
C7-H8-N2-O2 |
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| Major Category |
Nitrogen Compounds |
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| Synonyms |
AI3-01557; Amarthol Fast Scarlet G Base; Amarthol Fast Scarlet G Salt; 2-Amino-4-nitrotoluene; Azoene Fast Scarlet GC Base; Azoene Fast Scarlet GC Salt; Azofix Scarlet G Salt; Azogene Fast Scarlet G; Benzenamine, 2-methyl-5-nitro-; CI Azoic Diazo Component 12; CI 37105; Dainichi Fast Scarlet G Base; Daito Scarlet Base G; Devol Scarlet B; Devol Scarlet G Salt; Diabase Scarlet G; Diazo Fast Scarlet G; Fast Red SG Base; Fast Scarlet G; Fast Scarlet G Base; Fast Scarlet Base J; Fast Scarlet T Base; Fast Scarlet M4NT Base; Fast Scarlet GC Base; Fast Scarlet G Salt; Fast Scarlet J Salt; Hiltonil Fast Scarlet G Base; Hiltonil Fast Scarlet GC Base; Hiltonil Fast Scarlet G Salt; Kayaku Scarlet G Base; Lake Scarlet G Base; Lithosol Orange R Base; 2-Methyl-5-nitroaniline; 6-Methyl-3-nitroaniline; 2-Methyl-5-nitro-benzenamine; Mitsui Scarlet G Base; Naphthanil Scarlet G Base; Naphtoelan Fast Scarlet G Base; Naphtoelan Fast Scarlet G Salt; 4-Nitro-2-aminotoluene; 3-Nitro-6-methylaniline; PNOT; Scarlet G Base; Scarlet Base Ciba II; Scarlet Base IRGA II; Scarlet Base NSP Sugai Fast Scarlet G Base; Symulon Scarlet G Base; o-Toluidine, 5-nitro-; Nitro-o-toluidine; [HSDB] 4-Nitro-2-aminotoluene; [Guide to Occupational Exposure Values, 2002] UN2660 |
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| Category |
Nitros, Aromatic |
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| Description |
Yellow crystals; [ACGIH] |
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| Sources/Uses |
Workers are exposed during production or handling of more than 35 commercial dyes (orange or red) of which 5-nitro-o-toluidine is the major component; [ACGIH] |
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| Comments |
Several Japanese workers were admitted to the hospital with severe liver damage after handling repeatedly (12-20 times) 5-nitro-o-toluidine for 4-5 hours at a time. Workers had scooped the powder by hand while wearing respirators. [Gut 2002 Feb;50(2):266-70] Methemoglobinemia is a potential adverse effect after exposure to this agent. [HSDB] |
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| Reference Link |
Liver dysfunction among workers handling 5-nitro-o-toluidine |
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| Exposure Assessment |
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| Skin Designation (ACGIH) |
No |
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| TLV (ACGIH) |
1 mg/m3, inhalable fraction |
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| Vapor Pressure |
0.000975 mm Hg |
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| Adverse Effects |
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| Methemoglobinemia |
Methemoglobinemia, Secondary |
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| Hepatotoxin |
Hepatotoxin, Primary |
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| IARC Carcinogen |
Not Classifiable |
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| Links to Other NLM Databases |
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| Health Studies |
Human Health Effects from Hazardous Substances Data Bank: 5-NITRO-O-TOLUIDINE
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