| Agent Name |
Quinidine |
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| CAS Number |
56-54-2 |
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| Formula |
C20-H24-N2-O2 |
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| Major Category |
Other Uses |
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| Synonyms |
alpha-(6-Methoxy-4-quinolyl)-5-vinyl-2-quinuclidinemethanol (9S)-; Quindine; Cin-quin; Quinidine; Coccinine; Conchinine; (+)-Quinidine; beta-Quinidine; (9S)-6`-Methoxycinchonan-9-ol; Conquinine; 6`-Methoxy-alpha-(5-vinyl-2-quinuclidinyl)-4-quinolinemethanol; Pitayine; (+)-Quindine; Kinidin; [ChemFinder] |
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| Category |
Pharmaceuticals |
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| Sources/Uses |
Used as an antiarrhythmic drug; |
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| Comments |
Allergic contact dermatitis reported in pharmaceutical workers; Quinine and chloroquine are drugs structurally related to quinidine that also can cause allergic contact dermatitis in pharmaceutical workers. [Kanerva, p. 484-5] Quinidine may induce photosensitivity in patients taking it systemically (photodrug reaction). [Marks, p. 201-3] As an oral medication, quinidine is used to treat heart arrhythmias. Many side effects have been reported after ingestion of therapeutic doses, including immune hemolytic anemia and drug-induced hepatitis. [HSDB] Therapeutic serum levels are 2-4 mg/L, and serious adverse effects are unusual in that range. A one gram dose is potentially lethal to adults. Toxic effects include ventricular tachycardia and depression of cardiac contractility. Other symptoms are vomiting, diarrhea, and anticholinergic effects. Seizures and coma may follow. Symptoms of chronic poisoning (cinchonism) are tinnitus, vertigo, deafness, and visual dsturbances. [Olson, p. 326-7] |
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| Reference Link |
The lymphocyte transformation test for diagnosis of drug-induced occupational allergy |
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| Exposure Assessment |
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| Skin Designation (ACGIH) |
Not evaluated |
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| Adverse Effects |
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| Skin Sensitizer |
Yes |
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| Hepatotoxin |
Hepatotoxin, Secondary |
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| Links to Other NLM Databases |
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| Health Studies |
Human Health Effects from Hazardous Substances Data Bank: QUINIDINE
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