| Agent Name |
Crag herbicide |
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| Alternative Name |
Sesone |
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| CAS Number |
136-78-7 |
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| Formula |
C8-H7-Cl2-O5-S.Na |
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| Major Category |
Pesticides |
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| Synonyms |
2,4-Des sodium; 2,4-Des-Na; 2,4-Des-natrium [German]; 2,4-Dichlorophenoxyethyl hydrogen sulfate sodium salt; 2,4-Dichlorophenoxyethyl sulfate, sodium salt; 2-(2,4-Dichlorfenoxy)ethylsiran sodny [Czech]; 2-(2,4-Dichlorophenoxy)ethanol hydrogen sulfate sodium salt; 2-(2,4-Dichlorophenoxy)ethyl sulfate sodium salt; Crag herbicide 1; Crag herbicide I; Disul; Disul-Na; Disul-sodium; Experimental herbicide 1; Experimental herbicide I; Herbon 2,4-des-sodium; Natrium-2,4-dichlorphenoxyathylsulfat [German]; SES; Ses-T; Sesone; Sodium 2,4-dichlorophenoxyethyl sulfate; Sodium 2,4-dichlorophenoxyethyl sulphate; Sodium 2,4-dichlorophenyl cellosolve sulfate; Sodium 2-(2,4-dichlorophenoxy)ethyl sulfate; [ChemIDplus] |
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| Category |
Herbicides, Chlorophenoxy |
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| Description |
Colorless to white crystalline, odorless solid. [herbicide]; [NIOSH] |
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| Sources/Uses |
Herbicidal pre-emergence control of annual weeds; [HSDB] |
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| Comments |
Sesone is a gastrointestinal irritant. In animal experiments, it causes liver and kidney injury. [ACGIH] "Overall, it appears that the chlorophenoxy herbicides have led to little or no hepatic injury. Where sufficient occupational exposure seems to have led to hepatic abnormalities (e.g., toxic porphyria), the presumed chemical culprit has been the contaminating TCDD, rather than the herbicide per se." [Zimmerman, p. 415] |
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| Restricted |
The production of Crag herbicide in the United States was discontinued. [ACGIH] |
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| Exposure Assessment |
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| Skin Designation (ACGIH) |
No |
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| Bioaccumulates |
Yes |
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| TLV (ACGIH) |
10 mg/m3 |
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| PEL (OSHA) |
15 mg/m3(total dust), 5 mg/m3(respirable fraction) |
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| IDLH (NIOSH) |
500 mg/m3 |
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| Excerpts from Documentation for IDLHs |
Basis for revised IDLH: No inhalation toxicity data are available on which to base an IDLH for Crag� herbicide. Therefore, the revised IDLH for Crag� herbicide is 500 mg/m3 based on acute oral toxicity data in animals [Carpenter et al. 1961; Gunther 1962; Sine 1991]. This may be a conservative value due to the lack of acute toxicity data for workers. |
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| Vapor Pressure |
0.1 mm Hg |
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| Adverse Effects |
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| Hepatotoxin |
Hepatotoxin, Secondary |
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| Links to Other NLM Databases |
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| Health Studies |
Human Health Effects from Hazardous Substances Data Bank: SODIUM 2,4-DICHLOROPHENOXYETHYL SULFATE
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