| Agent Name |
2-Chloroaniline |
|---|
| Alternative Name |
o-Chloroaniline |
|---|
| CAS Number |
95-51-2 |
|---|
| Formula |
C6-H6-Cl-N |
|---|
| Major Category |
Nitrogen Compounds |
|---|
| Synonyms |
1-Amino-2-chlorobenzene; 2-Chloroaniline; 2-Chlorobenzenamine; 2-Chlorophenylamine; Aniline, o-chloro-; Benzenamine, 2-chloro-; Fast Yellow GC Base; o-Aminochlorobenzene; o-Chloraniline; o-Chloroaminobenzene; o-Chloroaniline; [ChemIDplus] UN2019 |
|---|
| Category |
Amines, Aromatic |
|---|
| Description |
Clear amber liquid with an amine odor; [CAMEO] |
|---|
| Sources/Uses |
Used as an intermediate for dyes, pesticides, and rubber chemicals; [HSDB] |
|---|
| Comments |
o-Chloroaniline is listed in a table "Examples of Industrial Chemicals for Which Methemoglobin Formation is the Principal Cause of Toxicity"; [ACGIH] "In the United Kingdom between 1961 and 1980, chloroaniline, p-toluidine, nitrobenzene, and nitrochlorobenzene were the most common industrial causes of methemoglobinemia. Dermal exposure was a more frequent route of toxicity than inhalation with these compounds." (Ellenhorn, M.J. and D.G. Barceloux. Medical Toxicology - Diagnosis and Treatment of Human Poisoning. New York, NY: Elsevier Science Publishing Co., Inc. 1988.) An eye irritant; Can induce methemoglobinemia; [ICSC] |
|---|
| Exposure Assessment |
|---|
| BEI |
Methemoglobin in blood = 1.5% of hemoglobin during or end of shift |
|---|
| Skin Designation (ACGIH) |
Not evaluated |
|---|
| Vapor Pressure |
0.2 mm Hg |
|---|
| Lethal Concentration |
LC50 (rats) = 797 ppm/4h |
|---|
| Explanatory Notes |
Flash point = 103 deg C; |
|---|
| Adverse Effects |
|---|
| Methemoglobinemia |
Methemoglobinemia, Primary |
|---|
| Links to Other NLM Databases |
|---|
| Health Studies |
Human Health Effects from Hazardous Substances Data Bank: 2-CHLOROANILINE
|
|---|
|
|
