| Agent Name |
Tetramethyl succinonitrile |
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| CAS Number |
3333-52-6 |
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| Formula |
C8-H12-N2 |
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| Major Category |
Toxic Gases & Vapors |
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| Synonyms |
2,2,3,3-Tetramethylbutanedinitrile; CP 75475; TMSN; Tetramethylbutanedinitrile; Tetramethylsuccinic acid dinitrile; Tetramethylsuccinodinitrile; Tetramethylsuccinonitrile; Tetramethylsuccinotrile; Tetramethylsukcinonitril [Czech]; [ChemIDplus] |
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| Category |
Nitriles |
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| Description |
Colorless, odorless solid; Note: Forms cyanide in the body; [NIOSH] |
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| Sources/Uses |
TMSN is a decomposition product formed from the heating of a blowing agent, azo-bisisobutyronitrile, during the production of vinyl foam; [ACGIH] |
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| Comments |
Convulsions and coma have been reported in workers manufacturing vinyl foam products. The toxicology is similar to that of other aliphatic nitriles. [ACGIH] |
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| Exposure Assessment |
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| Skin Designation (ACGIH) |
Yes |
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| TLV (ACGIH) |
0.5 ppm |
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| PEL (OSHA) |
0.5 ppm |
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| IDLH (NIOSH) |
5 ppm |
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| Excerpts from Documentation for IDLHs |
Basis for original (SCP) IDLH: The chosen IDLH is based on the statement by ACGIH [1972] that 6 ppm for 30 hours was lethal to rats [Spolyar 1948]. A concentration of 22 ppm is obviously too high to be chosen as the IDLH, because no mice survived a 3.5�hour exposure at this concentration [Hecht and Kimmerle 1956�1957 as quoted by Reinl 1957]. . . . Human data: None relevant for use in determining the revised IDLH. |
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| Lethal Concentration |
LCLo (rats) = 60 ppm/2H |
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| Explanatory Notes |
NIOSH REL = 0.5 ppm; |
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| Adverse Effects |
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| Other Poison |
Chemical Asphyxiant |
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| Links to Other NLM Databases |
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| Health Studies |
Human Health Effects from Hazardous Substances Data Bank: TETRAMETHYLSUCCINONITRILE
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