| Agent Name |
Sodium fluoroacetate |
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| CAS Number |
62-74-8 |
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| Formula |
C2-H3-F-O2.Na |
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| Major Category |
Pesticides |
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| Synonyms |
SFA; Sodium monofluoroacetate; [NIOSH] Fluoroacetic acid, sodium salt; Fratol; Furatol; Compound 1080; Ratbane 1080; Sodium fluoroacetic acid; 1018; 1080; [ACGIH] UN2629 |
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| Category |
Rodenticides |
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| Description |
Fluffy, colorless to white (sometimes dyed black), odorless powder. [Note: A liquid above 95 degrees F.] [rodenticide] [NIOSH] |
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| Sources/Uses |
Used to eliminate coyotes and rodents; [ACGIH] |
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| Comments |
A metabolic poison that combines with acetyl coenzyme A, causing the formation of fluorocitrate, which disrupts the Krebs cycle; Symptoms usually begin within 3 hours of ingestion. Patients die from ventricular fibrillation, frequently associated with hypokalemia and hypocalcemia. [Ford, p. 856-7] Very toxic by inhalation of dust, skin absorption, or ingestion; [CHEMINFO] 5 mg/kg is the estimated lethal oral dose for humans. After a lethal dose, death is preceded by seizures and ventricular fibrillation. [ACGIH] Damages the liver and kidneys in poisoning cases; [Merck Index] |
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| Exposure Assessment |
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| Skin Designation (ACGIH) |
Yes |
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| TLV (ACGIH) |
0.05 mg/m3 |
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| PEL (OSHA) |
0.05 mg/m3 |
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| MAK |
0.05 mg/m3, inhalable fraction |
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| IDLH (NIOSH) |
2 mg/m3 |
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| Excerpts from Documentation for IDLHs |
Human data: The probable oral lethal dose has been reported to be 50 mg [Deichmann and Gerarde 1969]. [Note: An oral dose of 50 mg is equivalent to a worker being exposed to about 30 mg/m3 for 30 minutes, assuming a breathing rate of 50 liters per minute and 100% absorption.] |
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| Explanatory Notes |
A non-combustible solid; Vapor pressure is approximately zero.[CHEMINFO] |
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| Adverse Effects |
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| Neurotoxin |
Other CNS Neurotoxin |
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| Hepatotoxin |
Hepatotoxin, Secondary |
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| Links to Other NLM Databases |
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| Health Studies |
Human Health Effects from Hazardous Substances Data Bank: SODIUM FLUOROACETATE
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