Cancer Control Research
5R03CA070738-02
Stotts, R. Craig
SPIT TOBACCO CESSATION IN ADOLESCENTS
AbstractAlthough the use of cigarettes is declining among all populations, the use
of spitting tobacco (ST) (particularly oral snuff) has doubled among
adolescent males in the last 15 years. The South currently has the highest
prevalence rates of any region in the country, but there are pockets of
high usage throughout the country. The use of spitting tobacco has been
causally linked to oral cancer, the incidence of which is higher in the
U.S. than cervical cancer. Besides the life-threatening link with cancer,
ST use has also been shown to cause significant dental problems including
tooth loss and periodontal disease. To date, nicotine replacement therapy
has not been tested on adolescent ST users, although it has been shown to
be effective for adult smokers.
This study is a pilot study of a Phase III (Controlled Intervention Trial)
study. It addresses the Healthy People 2000 goal (#3.9) of reducing
spitting tobacco use "among males aged 12-24 to a prevalence of no more
than 4%." The first aim of this study is to develop a behavioral
intervention program based on NCI-developed educational materials, to be
used in conjunction with a pharmacological adjunct, the transdermal
nicotine patch . The theoretical model for this intervention will be
Expectancy Theory. The second aim is to test recruitment and retention
methods that can be applied in a full-scale experimental study of
adolescent ST users. The third aim is to conduct a randomized, double-
blind, placebo-controlled, experimental study comparing the success rates
of three groups of adolescent ST users enrolled in a ST cessation program.
Subjects for this pilot study will be high school senior age males, who
are presently residing in the Little Rock area, who have been using ST
regularly for at least l year, and who want to quit. These subjects (N=60)
will be randomly divided into 3 groups; the first group will receive only
the "usual care" that would be offered to any ST user in a physician's
office: 3-5 minute counseling, distribution of self-help materials, and a
phone call two weeks later. The second group will receive the NCI-based
behavioral intervention that will involve six one-hour weekly sessions and
application of placebo transdermal patches, followed by one year of
regular, frequent telephone counseling. The third group will receive the
same intervention as Group Two but will receive active nicotine
transdermal patches. Changes in spitting tobacco use will be measured
immediately after the interventions, and every 3 months thereafter for l
year. Validation of abstinence immediately post-intervention and at l year
will be by urinary cotinine testing.
A health educator will provide the educational interventions, administer
the in-person surveys, and conduct the telephone surveys every 3 months.
The telephone surveys will include counseling to help abstainers "stay
quit" and to encourage recidivists to try again. Incentives will be
provided at every observation point and during the intervention. A special
newsletter on "staying quit" will be sent to all members of the two
experimental groups on a quarterly basis.
The findings from this pilot study will determine which recruitment and
retention methods work best in longitudinal studies of adolescents, what
success rates may generally be expected in each of the groups, and thus
will inform a larger study on the necessary sample size to reduce
attrition bias and to maintain adequate statistical power. A larger study
would then be able to better address the question of whether nicotine
transdermal batches serve as useful adjuncts to behavioral interventions
in adolescent populations.
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