What Causes Pulmonary Hypertension?
Pulmonary hypertension (PH) is the result of a
process that begins with changes in the cells that line your lungs' arteries.
This process includes three types of changes that affect the pulmonary
arteries:
- The walls of the arteries tighten.
- The walls of the arteries are stiff at birth or
become stiff from an overgrowth of cells.
- Blood clots form in the arteries.
These changes make it hard for the heart to push
blood through the arteries and into the lungs. Thus, the pressure in the
arteries rises, resulting in PH.
A number of different factors can contribute to the
process that leads to the different types of
PH.
Group 1 pulmonary arterial hypertension (PAH) may
have no known cause, or it may be inherited (passed from parents to children
through the genes). Certain diseases and conditions, such as
congenital
heart disease, HIV, and thyroid disease, also can cause this type of PH.
Also, the use of certain diet medicines and street drugs (such as cocaine) can
lead to this type of PH.
Many different diseases and conditions can lead to
the development of groups 2 through 5 PH (often called secondary PH),
including:
For more information about the types of PH and the
diseases, conditions, and factors that can contribute to PH, see
"Types of Pulmonary Hypertension." |