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Criteria for TNM Clinical Staging: Physical examination and results of radical orchiectomy.

Criteria for TNM Pathologic Staging: Extent of disease by histologic evaluation of radical orchiectomy specimen.

Note: evaluation of specimens from a defined node bearing area (such as retroperitoneal or periaortic) must be used. In other words, there must be a lymph node dissection for Pathologic Staging.

In the 6th edition of the AJCC staging manual, an additional descriptor, S (serum tumor markers) is required for stage grouping.

Brief Summaries of 6th Edition Categories

Tis   Intratubular
pT1
  Testis and epididymis, no vascular or lymphatic invasion
pT2   Testis and epididymis with vascular or lymphatic invasion, tunica vaginalis
pT3   Spermatic cord
pT4   Scrotum
     
N1   Nodal mass < 2 cm
N2   Nodal mass >2 but not more than 5 cm
N3   Any nodal mass > 5 cm
     
M1a   Non-regional lymph node or pulmonary metastasis
M1b   Distant metastasis other than to non-regional lymph nodes and lungs.
     
S1   LDH < 1.5 times normal AND hCG < 5,000 AND AFP < 1,000
S2   LDH 1.5-10 times normal OR hCG 5,000-50,000 OR AFP 1,000-10,000
S3   LDH > 10 times normal OR hCG > 50,000 OR AFP > 10,000

Collaborative Stage Elements

Fore more details on Collaborative Stage, see the CS module.

 

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