| Agent Name |
1,1,2,2-Tetrachloroethane |
|---|
| CAS Number |
79-34-5 |
|---|
| Formula |
C2-H2-Cl4 |
|---|
| Major Category |
Solvents |
|---|
| Synonyms |
1,1,2,2-T�trachloro �thane; Acetylene tetrachloride; sym-Tetrachloroethane; T�trachlorure d'ac�tyl�ne; 1,1,2,2-TCE; Tetrachloroethane (non-specific name); [CHEMINFO] UN1702 |
|---|
| Category |
Chlorinated Aliphatic |
|---|
| Description |
Colorless to pale-yellow liquid with a pungent, chloroform-like odor; [NIOSH] |
|---|
| Sources/Uses |
Used in synthesis of organic chemicals; used in the past as a solvent for degreasing and extracting; [ACGIH] |
|---|
| Comments |
Many cases of occupational toxic hepatitis were reported in the past. [ACGIH] At high enough concentrations, can induce lacrimation, narcosis, and liver damage; [CAMEO] |
|---|
| Exposure Assessment |
|---|
| Skin Designation (ACGIH) |
Yes |
|---|
| TLV (ACGIH) |
1 ppm |
|---|
| PEL (OSHA) |
5 ppm |
|---|
| MAK |
1 ppm |
|---|
| IDLH (NIOSH) |
100 ppm |
|---|
| Excerpts from Documentation for IDLHs |
Human data: A 30�minute exposure to 146 ppm has caused vertigo, irritation of the mucous membranes, sense of pressure in the head, and fatigue; the same effects were noted after a 10�minute exposure to 335 ppm [Lehmann et al. 1936; Negherbon 1959]. |
|---|
| Vapor Pressure |
4.62 mm Hg |
|---|
| Odor Threshold Low |
0.23 ppm |
|---|
| Odor Threshold High |
7.9 ppm |
|---|
| Lethal Concentration |
LCLo (rats) = 1,000 ppm/4H |
|---|
| Explanatory Notes |
Detection odor threshold from AIHA (mean = 7.3 ppm); |
|---|
| Reference Link |
ATSDR - ToxFAQs - 1,1,2,2-Tetrachloroethane |
|---|
| Adverse Effects |
|---|
| Neurotoxin |
CNS Solvent Syndrome |
|---|
| Hepatotoxin |
Hepatotoxin, Primary |
|---|
| Nephrotoxin |
Yes |
|---|
| IARC Carcinogen |
Not Classifiable |
|---|
| Links to Other NLM Databases |
|---|
| Health Studies |
Human Health Effects from Hazardous Substances Data Bank: 1,1,2,2-TETRACHLOROETHANE
|
|---|
|
|
