| Agent Name |
Warfarin |
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| CAS Number |
81-81-2 |
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| Formula |
C19-H16-O4 |
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| Major Category |
Pesticides |
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| Synonyms |
(Phenyl-1 acetyl-2 ethyl) 3-hydroxy-4 coumarine [French]; 1-(4'-Hydroxy-3'-coumarinyl)-1-phenyl-3-butanone; 200 coumarin; 2H-1-Benzopyran-2-one, 4-hydroxy-3-(3-oxo-1-phenylbutyl)-; 3-(1'-Phenyl-2'-acetylethyl)-4-hydroxycoumarin; 3-(alpha-Phenyl-beta-acetylaethyl)-4-hydroxycumarin [German]; 3-(alpha-Phenyl-beta-acetylethyl)-4-hydroxycoumarin; 4-Hydroxy-3-(3-oxo-1-fenyl-butyl) cumarine [Dutch]; 4-Hydroxy-3-(3-oxo-1-phenyl-butyl)-cumarin [German]; 4-Hydroxy-3-(3-oxo-1-phenylbutyl)-2H-1-benzopyran-2-one; 4-Hydroxy-3-(3-oxo-1-phenylbutyl)coumarin; 4-Idrossi-3-(3-oxo-1-fenil-butil)-cumarine [Italian]; Arab Rat Death; Athrombine-K; Brumolin; CO-Rax; Compound 42; Coumadin; Coumafen; Coumafene; Coumafene [French]; Coumaphene; Coumarin, 3-(alpha-acetonylbenzyl)-4-hydroxy-; Coumarins; Coumefene; Cov-R-Tox; DL-3-(alpha-Acetonylbenzyl)-4-hydroxycoumarin; Dethmor; Dethnel; Dicusat E; Eastern states duocide; Fasco fascrat powder; Frass-ratron; Kumader; Kumadu; Kumatox; Kypfarin; Latka 42 [Czech]; Liqua-tox; Maag rattentod cum; Mar-frin; Martin's mar-frin; Maveran; Mouse pak; Panwarfin; Place-Pax; Prothromadin; Rat & mice bait; Rat-A-way; Rat-B-gon; Rat-Gard; Rat-Kill; Rat-Mix; Rat-O-cide #2; Rat-Trol; Rat-o-cide #2; Rat-ola; Ratorex; Ratox; Ratoxin; Ratron; Ratron G; Rats-No-More; Ratten-koederrohr; Rattenstreupulver Neu Schacht; Rattenstreupulver new schacht; Rattentraenke; Rattunal; Rax; Ro-Deth; Rodafarin; Rodafarin C; Rodex blox; Rosex; Rough & ready mouse mix; Solfarin; Spray-trol brand roden-trol; Temus W; Tox-Hid; Twin light rat away; Vampirinip II; Vampirinip III; W.A.R.F. 42; Warf 42; Warf compound 42; Warfarat; Warfarin Q; Warfarin plus; Warfarin plus [discontinued]; Warfarina [INN-Spanish]; Warfarine [INN-French]; Warfarine [ISO-French]; Warfarinum [INN-Latin]; Zoocoumarin [Netherlands and USSR]; Zoocoumarin [Russian]; d-Con; rac-Warfarin; [ChemIDplus] |
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| Category |
Rodenticides, Anticoagulant |
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| Description |
Colorless, odorless, crystalline powder. [rodenticide]; [NIOSH] |
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| Sources/Uses |
Warfarin and its sodium salt are registered for use in controlling rats and mice; has been used successfully against common vampire bats; a blood anticoagulant; its sodium salt is used medically to treat people with blood hypercoagulation problems; [HSDB] |
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| Comments |
There is one report of a farmer developing symptoms after prolonged skin contact of a liquid formulation. No other cases after occupational exposure have been reported. [LaDou, p. 564] There are rare case reports of acute liver injury caused by high-dose Warfarin ingestion. [Zimmerman, p. 330] Can cause nonimmunologic contact urticaria; [Kanerva 2004, p. 102] |
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| Reference Link |
EXTOXNET PIP - WARFARIN |
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| Exposure Assessment |
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| Skin Designation (ACGIH) |
No |
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| TLV (ACGIH) |
0.1 mg/m3 |
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| PEL (OSHA) |
0.1 mg/m3 |
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| MAK |
0.5 mg/m3, inhalable fraction |
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| IDLH (NIOSH) |
100 mg/m3 |
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| Excerpts from Documentation for IDLHs |
Basis for revised IDLH: No inhalation toxicity data are available on which to base an IDLH for warfarin. Therefore, the revised IDLH for warfarin is 100 mg/m3 based on acute toxicity data in humans [Yakkyoku 1977]. This may be a conservative value due to the lack of acute inhalation toxicity data for workers. |
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| Vapor Pressure |
0.09 mm Hg |
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| Adverse Effects |
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| Hepatotoxin |
Hepatotoxin, Secondary |
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| Links to Other NLM Databases |
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| Health Studies |
Human Health Effects from Hazardous Substances Data Bank: WARFARIN
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