Phospho-PKC (pan) (gamma Thr514) Antibody is provided by Cell Signaling Technology

Antibody Name Phospho-PKC (pan) (gamma Thr514) Antibody
AntibodyPhosphoID 707
Polyclonal
Species Rabbit
Sequence Representative MDGVTTRpTFCGTPDY
Company Name Cell Signaling Technology
Catalog #: Primary 9379
Catalog #: Other
Derived Url http://www.cellsignal.com/products/9379.html
Designated Phosphorylation Sites
Gene/Protein Phosphorylation Sites
Symbol
Name 		Site Name Alt Res Names Local Sequence MPR Site ID Refs
PRKCB1
PKC-beta1
Genbank LocusLink
T500 VTTKpTFCGT 683
PRKCB1
PKC-beta2
Genbank LocusLink
T500 VTTKpTFCGT 475
PRKCA
pkc-alpha
Genbank LocusLink
T497 VTTRpTFCGT 360
PRKCD
pkc-delta
Genbank LocusLink
T507 T505 SRASpTFCGT 295 1, 2, 3, 4, 5, 6
PRKCE
pkc-epsilon
Genbank LocusLink
T566 VTTTpTFCGT 477
PRKCH
pkc-eta
Genbank LocusLink
T512 VTTApTFCGT 478
PRKCG
pkc-gamma
Genbank LocusLink
T514 TTTRpTFCGT 476
PRKCQ
pkc-theta
Genbank LocusLink
T538 AKTNpTFCGT 183 3

    References

  1. Balendran A, Hare GR, Kieloch A, Williams MR, Alessi DR. 2000. Further evidence that 3-phosphoinositide-dependent protein kinase-1 (PDK1) is required for the stability and phosphorylation of protein kinase C (PKC) isoforms. FEBS Lett 484:217-223 (Abstract) [site(s): T507]
  2. Le Good JA, Ziegler WH, Parekh DB, Alessi DR, Cohen P, Parker PJ. 1998. Protein kinase C isotypes controlled by phosphoinositide 3-kinase through the protein kinase PDK1. Science 281:2042-2045 (Abstract) [site(s): T507]
  3. Liu Y, Graham C, Li A, Fisher RJ, Shaw S. 2002. Phosphorylation of PKC-theta activation loop and hydrophobic motif regulate its kinase activity but only activation loop phosphorylation is critical to in vivo NFkB induction. Biochem J 361:255-65 (Abstract) [site(s): T507,T538]
  4. Rybin VO, Sabri A, Short J, Braz JC, Molkentin JD, Steinberg SF. 2003. Cross regulation of nPKC isoform function in cardiomyocytes: Role of PKCepsilon in activation loop phosphorylations and PKCdelta in hydrophobic motif phosphorylations. J Biol Chem : (Abstract) [site(s): T507]
  5. Stempka L, Girod A, Muller HJ, Rincke G, Marks F, Gschwendt M, Bossemeyer D. 1997. Phosphorylation of protein kinase Cdelta (PKCdelta) at threonine 505 is not a prerequisite for enzymatic activity. Expression of rat PKCdelta and an alanine 505 mutant in bacteria in a functional form. J Biol Chem 272:6805-6811 (Abstract) [site(s): T507]
  6. Stempka L, Schnolzer M, Radke S, Rincke G, Marks F, Gschwendt M. 1999. Requirements of protein kinase C delta for catalytic function. Role of glutamic acid 500 and autophosphorylation on serine 643. J Biol Chem 274:8886-8892 (Abstract) [site(s): T507]