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Organism

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Chemical Name: N-(1,1-Dimethylethyl)-3-[2-hydroxy-3-[[2-[[(5-isoquinolinyloxy)acetyl]amino]-3-methylthio)-1-oxopropyl]amino]-1-oxo-4-phenylbutyl]-5,5-dimethyl]-4-thiazolidinecarboxamide,[4R-[3[2S*,3S*(R*)],4R*]] Synonyms

  • KNI-227
  • Qoa-Mta-Apns-Thz-NH-tBu
  • Kynostatin 227
  • Kynostatin-227
AIDS# 006772
Click For Structure Based Search Links to ChemID Plus by CAS#

147384-69-8

Links to PubChem by AIDS#

006772


 
C35 H45 N5 O6 S2  MW: 695.9 Links to PubMed by CAS#

H-bond donors: 4 H-bond acceptors: 13 PHIA (Flexible Bonds): 13.07 Calc. LogP
(MDL QSAR): 7.4
Company:  NIKKO KYODO CO. Calc. LogP
(KowWin): 1.22

Lines of Data: 21

Lines of Data: 15
Anti-OI data: 0
TB Min MIC

   
TB Min IC50

   
Links to NIST by AIDS#

006772

Number of References: 5

Number of References: 6
Number of References: 0
Lipinski:    1                     (Score, out of 4)
Classes: PEPTIDOMIMETICS, PSEUDO PHENYLALANINE HYDROXYMETHYLENE THIAZOLIDINE; HIV PROTEASE INHIBITORS; ISOQUINOLINES

 



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