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Model Characteristics - Model:
ACI rat model of estradiol induced mammary cancer
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| Model Descriptor |
ACI rat model of estradiol induced mammary cancer
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| Official Nomenclature |
ACI/SegHsd
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| Genotype |
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| Species |
Rat (Rattus norvegicus)
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| Strain |
ACI
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| Is This a Tool Strain? |
No
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Developmental Stage
(applies only to Zebrafish) |
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| Experimental Design |
The ACI rat strain was originally derived by Dunning and Curtis in 1926. The ACI/SegHsd rat is commercially available from Harlan.
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| Phenotype |
The ACI rat is highly susceptible to mammary cancer development when treated continuously with 17beta-estradiol, administered from subcutaneous implants. Ovary-intact ACI rats treated in this manner beginning at 63 days of age develop mammary carcinoma at an incidence approaching 100% and a median latency of 140 days. Multiple mammary carcinoma develop per treated rat. In contrast, the ACI rat is resistant to spontaneously arising mammary cancer as well as mammary cancers induced by dimethylbenz[a]anthracene. Mammary cancers appear to arise from well defined focal regions of atypical epithelial hyperplasia. Ovariectomy markedly inhibits development of estradiol-induced mammary cancer in this model.
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| Website for add. info |
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| Breeding Notes |
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| Sex Distribution of the Phenotype |
Both Sexes
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| Submitted by |
Shull, James
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| Principal Investigator / Lab |
Shull, James
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| Comment |
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| Model Availability: This model is available from |
| Strain |
Distributor |
Stock number |
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 Comments (Please login to submit new comments) |
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