Better Tools and Better Knowledge for Structural Genomics

The Protein Structure Initiative (PSI) is a federal, university, and industry effort to reduce the costs and lessen the time it takes to determine a three-dimensional protein structure. The long-range goal of the PSI is to make the three-dimensional atomic-level structures of most proteins easily obtainable from knowledge of their corresponding DNA sequences. Expected benefits from the PSI include: structural descriptions to help researchers discover the functions of proteins, design experiments, and solve other key biomedical problems; faster identification of promising new structure-based medicines; better therapeutics for treating both genetic and infectious diseases; and development of technology and methodology for protein production and crystallography. For more details about the PSI's goals, organization, and benefits, see the PSI Mission Statement. Additional information about the PSI can be found under the links listed below.